Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome

Summary

The investigators aim to assess the respiratory effect of short half-life agents in balanced anesthesia on patients suffering from non-treated or suspected obstructive sleep apnea syndrome (OSA) We will study the impact on OSA of a regimen of remifentanil-desflurane versus a regimen of fentanyl-sevoflurane. Each patient will undergo three respiratory portable polygraphies: the night before the surgery ; the first night following the surgery ; the third night following the surgery.

Timeline

Start

2016-02

Primary completion

2018-06

Completion

2018-06

Outcome

Missed primary endpoint

paper were 20 (16-25) and 21 (16-26) events h-1 (P=0.82), respectively; corresponding values on the third postoperative night were 34 PMID 38862381 ↗

paper Use of spinal anaesthesia compared with general anaesthesia was not associated with a reduction in postoperative sleep apnoea severity PMID 38862381 ↗

Publications

• Albrecht E, Wegrzyn J, Rossel JB, Bayon V, Heinzer R. Impact of spinal versus general anaesthesia on perioperative obstructive sleep apnoea severity in patients undergoing hip arthroplasty: a post hoc analysis of two randomised controlled trials. Br J Anaesth. 2024 Aug;133(2):416-423. doi: 10.1016/j.bja.2024.04.051. Epub 2024 Jun 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Desflurane	Other / unclassified	—	—
Comparator	Fentanyl	Other / unclassified	—	—
Subject	Remifentanil	Small molecule	—	—
Comparator	Sevoflurane	Other / unclassified	—	—

Indications