drugset / Trial / NCT03996148

Time to Post-Anesthesia Neurological Evaluation With Three Different Anesthetic Techniques

NCT03996148

Phase 4 Completed 21 enrolled The Cooper Health System
RandomizedParallel-groupSingle-blindTreatment

Summary

The objective of this pilot study is to analyze the differences in time to first postoperative neurological examination (cranial nerve XII - tongue movement, movement of extremities) and intraoperative hemodynamic stability with three different general anesthetic techniques that are used for carotid endarterectomy. Carotid endarterectomy surgery removes the plaque and stenosis but has a 1-3% risk of periprocedural stroke or death. The ability to detect neurological abnormalities early after surgery is vital in this patient population to facilitate timely additional diagnostics or interventions if a potential stroke is detected. Anesthetic techniques that facilitate an earlier reliable neurological exam will thus greatly benefit this surgical patient population. The primary objective of this pilot study is to determine the time difference from end of surgery to first neurologic exam between three commonly used anesthetic methods for carotid endareterectomy.

Timeline

Start
2017-09-29
Primary completion
2018-09-19
Completion
2018-09-19

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexmedetomidine Other / unclassified 0.5 ug/kg
Comparator Propofol Small molecule 75 ug/kg
Comparator Desflurane Other / unclassified 0.5 unknown
Comparator Remifentanil Small molecule 0.05 ug/kg

Indications