drugset / Trial / NCT02342509
Automated Control of End-tidal Volatile Anesthetic Concentration
RandomizedParallel-groupSingle-blindHealth-services research
Summary
The new MIRUS system as well as the established AnaConDa system uses a reflector to conserve volatile anaesthetics (VA). Both systems act with commercially available ICU ventilators. In contrast to AnaConDa the MIRUS includes an automated control of end-tidal VA concentrations. In this study the investigators compared feasibility, costs and recovery times after anaesthesia with isoflurane (ISO), sevoflurane (SEVO) or desflurane (DES) in ventilated and spontaneously breathing patients.
Timeline
- Start
- 2014-09
- Primary completion
- 2014-12
- Completion
- 2014-12
Publications
- Background Bomberg H, Glas M, Groesdonk VH, Bellgardt M, Schwarz J, Volk T, Meiser A. A novel device for target controlled administration and reflection of desflurane--the Mirus. Anaesthesia. 2014 Nov;69(11):1241-50. doi: 10.1111/anae.12798. Epub 2014 Jul 9.
- Background Meiser A, Sirtl C, Bellgardt M, Lohmann S, Garthoff A, Kaiser J, Hugler P, Laubenthal HJ. Desflurane compared with propofol for postoperative sedation in the intensive care unit. Br J Anaesth. 2003 Mar;90(3):273-80. doi: 10.1093/bja/aeg059.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Desflurane | Other / unclassified | 5 % | — |
| Subject | Desflurane | Other / unclassified | 6 % | — |
| Comparator | Isoflurane | Other / unclassified | 0.9 % | — |
| Comparator | Isoflurane | Other / unclassified | 1.2 % | — |
| Subject | Sevoflurane | Other / unclassified | 1.4 % | — |
| Subject | Sevoflurane | Other / unclassified | 2.1 % | — |
Indications
No indication recorded.