drugset / Trial / NCT05866315
The Effect of Remimazolam on Opioid Induced Hyperalgesia
RandomizedParallel-groupTriple-blindPrevention
Summary
The goal of this prospective, randomized, controlled study is to investigate the effect of remimazolam on opioid-induced hyperalgesia (OIH) in patients undergoing single port-laparoscopically assisted urologic surgery. The main question\[s\] it aims to answer are: * \[The mechanical hyperalgesia threshold\] * \[Area of hyperalgesia around the surgical incision 24 h after surgery (cm\^2)\] In three groups: Group RHR (Remimazolam- High-dose Remifentanil), Group DHR (Desflurane-low-dose Remifentanil) or Group DLR (Control).
Timeline
- Start
- 2023-05-19
- Primary completion
- 2023-09-06
- Completion
- 2023-09-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Desflurane | Other / unclassified | 1 unknown | — |
| Subject | Remifentanil | Small molecule | 0.025 ug/kg | — |
| Subject | Remifentanil | Small molecule | 0.3 ug/kg | — |
| Subject | Remimazolam | Small molecule | 1 mg/kg | — |
Indications
No indication recorded.