Drugs / Remimazolam
Remimazolam
also known as
remimazolam besylate · Byfavo · Remimazolam Tosilate · remimazolam tosylate · CNS 7056 · HR7056 · Anerem · Aptimyda · +15 more
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | EU (EMA) | Byfavo | — | 2021-03-26 | europa.eu ↗ |
| Approved | US (FDA) | BYFAVO | — | 2020-07-02 | fda.gov ↗ |
Trials 207 · started per year
today
US approved 2020
EU approved 2021
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 04 trials | ||||||
| Phase 0 | NCT07290205 | Mar 2026 → Dec 2027 expected | — | Keith M Vogt | Recruiting | No outcome recorded |
| Phase 0 | NCT07012902 | Jun 2025 overdue | — | Second Hospital of Shanxi Medical University | Not yet recruiting | No outcome recorded |
| Phase 0 | NCT06756178 | Jan 2025 → Nov 2026 expected | delirium | Assiut University | Not yet recruiting | No outcome recorded |
| Phase 0 | NCT06717945 | Jan → May 2025 overdue | — | Chinese Academy of Medical Sciences, Fuwai Hospital | Not yet recruiting | No outcome recorded |
| Phase 111 trials | ||||||
| Phase 1 | NCT07045467 | Jul 2025 → Jul 2026 overdue | chronic kidney disease | Qianfoshan Hospital | Recruiting | No outcome recorded |
| Phase 1 | NCT06129188 | Feb → Nov 2025 | — | University of Alabama at Birmingham | Completed | No outcome recorded |
| Phase 1 | NCT07704437 | Apr 2024 → Jul 2025 | delirium | University Hospital of Split | Completed | No outcome recorded |
| Phase 1 | NCT04670471 | Apr 2021 → Jan 2022 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT04113343 | May → Aug 2017 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT03329014 | May → Jun 2017 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT04113564 | Nov 2015 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT04110535 | Jun → Oct 2015 | substance abuse | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT03444480 | Jul → Aug 2014 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT01970072 | Oct 2013 → Jun 2014 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 1 | NCT01790607 | Feb → Nov 2013 | — | Ono Pharma USA Inc | Completed | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT07086911 | Aug 2025 → Aug 2026 overdue | — | Jinqiao Qian | Not yet recruiting | No outcome recorded |
| Phase 1/2 | NCT05913336 | Jun 2023 → Mar 2025 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 216 trials | ||||||
| Phase 2 | NCT06398275 | Mar → Sep 2024 | delirium | University Hospital of Split | Unknown | No outcome recorded |
| Phase 2 | NCT06275594 | Mar 2024 → Feb 2025 | — | Yeungnam University Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT05975255 | Nov 2023 → Oct 2024 | — | Seoul National University Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT06153498 | Nov 2023 → Dec 2024 | — | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Unknown | No outcome recorded |
| Phase 2 | NCT05152303 | Oct 2022 → Apr 2023 | — | Fujian Shengdi Pharmaceutical Co., Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT05539521 | Sep 2022 → Feb 2023 | — | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Unknown | No outcome recorded |
| Phase 2 | NCT05635955 | Aug → Sep 2022 | — | Maternal and Child Health Hospital of Hubei Province | Completed | No outcome recorded |
| Phase 2 | NCT06124404 | Apr 2022 → Feb 2023 | — | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Completed | No outcome recorded |
| Phase 2 | NCT04790734 | May 2021 → Apr 2022 | — | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Completed | No outcome recorded |
| Phase 2 | NCT05015361 | May → Jun 2021 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT04611425 | Nov → Dec 2020 | COVID-19, acute respiratory failure, infectious disease with sepsis, stroke disorder | Nantes University Hospital | Completed | No outcome recorded |
| Phase 2 | NCT03003884 | Nov 2016 → Mar 2017 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT02406872 | Dec 2014 → Aug 2015 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT01937767 | Aug 2013 → Feb 2014 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT01145222 | May → Sep 2010 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 2 | NCT00869440 | Mar → Sep 2009 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 2/32 trials | ||||||
| Phase 2/3 | NCT07036419 | Jul 2025 → May 2026 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 2/3 | NCT04851717 | Nov 2021 → Oct 2027 expected | childhood acute lymphoblastic leukemia | Acacia Pharma Ltd | Active not recruiting | No outcome recorded |
| Phase 323 trials | ||||||
| Phase 3 | NCT07269808 | Mar → Jul 2026 overdue | — | Massachusetts General Hospital | Active not recruiting | No outcome recorded |
| Phase 3 | NCT07303985 | Dec 2025 → Feb 2026 | — | Jun Zhang | Completed | No outcome recorded |
| Phase 3 | NCT07155265 | Oct 2025 → Jun 2027 expected | respiratory failure | Yancheng First People's Hospital | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07596589 | Apr 2025 → Jan 2027 expected | — | Southeast University, China | Recruiting | No outcome recorded |
| Phase 3 | NCT06714669 | Jun → Oct 2024 | — | Sun Yat-sen University | Completed | No outcome recorded |
| Phase 3 | NCT06222294 | Mar → Aug 2024 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT06013345 | Oct 2023 → Sep 2024 | atrial fibrillation | Charles University, Czech Republic | Completed | No outcome recorded |
| Phase 3 | NCT05555667 | May 2023 → Nov 2025 | — | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Unknown | No outcome recorded |
| Phase 3 | NCT05836545 | Apr 2023 → Jan 2024 | — | Samsung Medical Center | Completed | No outcome recorded |
| Phase 3 | NCT05782894 | Feb → Nov 2023 | — | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Completed | No outcome recorded |
| Phase 3 | NCT05635201 | Dec 2022 → Sep 2023 | — | Daegu Catholic University Medical Center | Completed | No outcome recorded |
| Phase 3 | NCT05220462 | Mar 2022 → May 2024 | — | Guy's and St Thomas' NHS Foundation Trust | Unknown | No outcome recorded |
| Phase 3 | NCT04947345 | Sep 2021 → Mar 2022 | — | Peking Union Medical College Hospital | Unknown | No outcome recorded |
| Phase 3 | NCT04400201 | Jun → Oct 2020 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT03921775 | May → Dec 2019 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT03661489 | Jul 2018 → Apr 2020 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT03779061 | Jun → Sep 2018 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT03425474 | Sep → Nov 2017 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT03669484 | Aug 2017 → May 2018 | — | R-Pharm | Completed | No outcome recorded |
| Phase 3 | NCT02532647 | Nov 2015 → Dec 2016 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT02523859 | Jul 2015 → Mar 2016 | — | Paion UK Ltd. | Terminated | No outcome recorded |
| Phase 3 | NCT02296892 | Apr 2015 → Mar 2017 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT02290873 | Mar 2015 → Apr 2016 | — | Paion UK Ltd. | Completed | No outcome recorded |
| Phase 460 trials | ||||||
| Phase 4 | NCT07325227 | Sep 2026 → Jan 2028 expected | cataract | Fred E, Shapiro | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07651956 | Jun 2026 → May 2028 expected | anxiety | Icahn School of Medicine at Mount Sinai | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07663877 | Jun 2026 → Jun 2028 expected | — | Chung-Ang University Gwangmyeong Hospital | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07611344 | May → Dec 2026 expected | — | Xuyu Zhang | Recruiting | No outcome recorded |
| Phase 4 | NCT07395596 | Feb → Dec 2026 expected | infectious disease, lung disorder, lymphangiectasis, trachea neoplasm | First Affiliated Hospital of Zhejiang University | Recruiting | No outcome recorded |
| Phase 4 | NCT07265128 | Dec 2025 → Sep 2027 expected | delirium | Yonsei University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07194109 | Oct 2025 → Oct 2030 expected | disorder of pharynx | The First Affiliated Hospital of Anhui Medical University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07118579 | Sep 2025 → Aug 2026 overdue | — | Tongji Hospital | Recruiting | No outcome recorded |
| Phase 4 | NCT07094945 | Aug 2025 → Aug 2026 overdue | — | Tongji Hospital | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT06793358 | Jul 2025 → Feb 2026 | — | Indiana University | Withdrawn | No outcome recorded |
| Phase 4 | NCT06690424 | Jun → Dec 2025 | — | Affiliated Hospital of Nantong University | Completed | No outcome recorded |
| Phase 4 | NCT06998732 | Jun → Sep 2025 overdue | uremia | Gang Chen | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT05980117 | Mar → Dec 2025 overdue | cataract, cognitive disorder | University of California, Los Angeles | Recruiting | No outcome recorded |
| Phase 4 | NCT06784479 | Mar 2025 → Mar 2026 overdue | obstructive sleep apnea syndrome | Dan Liu | Active not recruiting | No outcome recorded |
| Phase 4 | NCT06777758 | Feb 2025 → Dec 2026 expected | constipation disorder, respiratory underresponsiveness to hypoxia and hypercapnia | Kaohsiung Veterans General Hospital. | Recruiting | No outcome recorded |
| Phase 4 | NCT06816173 | Feb 2025 → Jan 2026 overdue | respiratory underresponsiveness to hypoxia and hypercapnia | Second Affiliated Hospital of Wenzhou Medical University | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT06575530 | Jan 2025 → May 2026 overdue | — | Beijing Shijitan Hospital, Capital Medical University | Recruiting | No outcome recorded |
| Phase 4 | NCT07046364 | Jan 2025 → Jan 2027 expected | delirium | Peking University First Hospital | Recruiting | No outcome recorded |
| Phase 4 | NCT07456111 | Jan 2025 → Nov 2027 expected | polyp of colon | Clinical Hospital Centre Zagreb | Recruiting | No outcome recorded |
| Phase 4 | NCT06614036 | Oct 2024 → Dec 2025 overdue | — | Koen Munters | Recruiting | No outcome recorded |
| Phase 4 | NCT06565715 | Aug → Oct 2024 | — | Jun Zhang | Completed | No outcome recorded |
| Phase 4 | NCT06382467 | May 2024 → May 2025 | nervous system disorder | Chung-Ang University Gwangmyeong Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT06303037 | Apr → Aug 2024 | — | Second Affiliated Hospital of Wenzhou Medical University | Completed | No outcome recorded |
| Phase 4 | NCT06333145 | Feb 2024 → Jun 2026 | — | Tongji Hospital | Completed | No outcome recorded |
| Phase 4 | NCT06214117 | Feb 2024 → Feb 2025 | delirium | Second Affiliated Hospital of Wenzhou Medical University | Unknown | No outcome recorded |
| Phase 4 | NCT06507202 | Jan 2024 → Jan 2025 overdue | disorder of pharynx, laryngeal disorder, mouth disorder, nasal disorder | Chung-Ang University Gwangmyeong Hospital | Recruiting | No outcome recorded |
| Phase 4 | NCT05758597 | Jan 2024 → May 2025 | acute respiratory distress syndrome | Zhiming Jiang | Unknown | No outcome recorded |
| Phase 4 | NCT06216444 | Jan → Mar 2024 | — | Jiangsu HengRui Medicine Co., Ltd. | Unknown | No outcome recorded |
| Phase 4 | NCT06169995 | Dec 2023 | — | Jiangsu HengRui Medicine Co., Ltd. | Completed | No outcome recorded |
| Phase 4 | NCT06061159 | Oct 2023 → Feb 2024 | — | Second Affiliated Hospital of Wenzhou Medical University | Completed | No outcome recorded |
| Phase 4 | NCT06664138 | Apr 2023 → Jan 2024 | bipolar disorder, major depressive disorder, schizoaffective disorder, schizophrenia | Yeongseok Yun | Completed | No outcome recorded |
| Phase 4 | NCT05728775 | Apr 2023 → Dec 2027 expected | — | Nanfang Hospital, Southern Medical University | Recruiting | No outcome recorded |
| Phase 4 | NCT05760534 | Mar 2023 → Nov 2025 | arthropathy | Seoul National University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT06513923 | Feb → Sep 2023 | — | Central South University | Completed | No outcome recorded |
| Phase 4 | NCT05412914 | Jan 2023 → Jan 2024 | — | Konkuk University Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT05624424 | Nov 2022 → Oct 2023 | — | Second Affiliated Hospital of Nanchang University | Unknown | No outcome recorded |
| Phase 4 | NCT05856617 | Oct 2022 → Aug 2023 | morbid obesity | Seoul National University Bundang Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT05436522 | Aug 2022 → May 2024 | — | Nanfang Hospital, Southern Medical University | Completed | No outcome recorded |
| Phase 4 | NCT05423080 | Aug → Nov 2022 | — | Korea University Guro Hospital | Completed | No outcome recorded |
| Phase 4 | NCT05486377 | Aug 2022 → May 2023 | cardiac rhythm disease | Seoul National University Bundang Hospital | Completed | No outcome recorded |
| Phase 4 | NCT05406102 | Jul 2022 → May 2023 | — | First Affiliated Hospital Xi'an Jiaotong University | Unknown | No outcome recorded |
| Phase 4 | NCT05429086 | Jun → Aug 2022 | — | Sichuan Provincial People's Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT05379777 | May → Aug 2022 | — | Asan Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT05340335 | Apr → May 2022 | — | Asan Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT05644483 | Mar 2022 → Jan 2023 | — | Asan Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT05606315 | Mar 2022 → Jan 2025 | — | Nanfang Hospital, Southern Medical University | Terminated | No outcome recorded |
| Phase 4 | NCT05554965 | Feb → Oct 2022 | — | Renmin Hospital of Wuhan University | Unknown | No outcome recorded |
| Phase 4 | NCT05480787 | Feb → Aug 2022 | liver failure | The First Affiliated Hospital with Nanjing Medical University | Unknown | No outcome recorded |
| Phase 4 | NCT05255211 | Dec 2021 → Dec 2024 | — | RenJi Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT05041725 | Nov 2021 → Nov 2022 | coronary artery disorder | Konkuk University Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT04969068 | Jul → Dec 2021 | — | Tianjin Nankai Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT04908553 | Jul 2021 → Mar 2025 | — | Tongji Hospital | Completed | No outcome recorded |
| Phase 4 | NCT04861337 | May 2021 → Dec 2022 | — | Peking University First Hospital | Completed | No outcome recorded |
| Phase 4 | NCT04919174 | Apr 2021 → Apr 2022 | — | Second Affiliated Hospital, School of Medicine, Zhejiang University | Unknown | No outcome recorded |
| Phase 4 | NCT04815265 | Apr 2021 → Dec 2023 | — | Tianjin Nankai Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT04602845 | Apr → Jun 2021 | — | Peking University | Completed | No outcome recorded |
| Phase 4 | NCT04720963 | Feb 2021 → Feb 2022 | mixed anxiety and depressive disorder | Second Affiliated Hospital of Wenzhou Medical University | Completed | No outcome recorded |
| Phase 4 | NCT04532606 | Feb 2021 → Oct 2025 overdue | delirium, urinary bladder cancer | Peking University First Hospital | Recruiting | No outcome recorded |
| Phase 4 | NCT05468671 | Jan → Aug 2021 | bronchial neoplasm | Zhejiang Cancer Hospital | Completed | No outcome recorded |
| Phase 4 | NCT04621305 | Nov 2020 → Nov 2021 | delirium | Second Affiliated Hospital of Wenzhou Medical University | Unknown | No outcome recorded |
| Phase not applicable89 trials | ||||||
| — | NCT07674719 | Jun 2026 → Jun 2027 expected | acute kidney injury | Seoul National University Bundang Hospital | Not yet recruiting | No outcome recorded |
| — | NCT07620782 | May 2026 → Apr 2027 expected | — | Pusan National University Yangsan Hospital | Recruiting | No outcome recorded |
| — | NCT07251101 | May 2026 → Oct 2027 expected | — | Ilsan Cha hospital | Not yet recruiting | No outcome recorded |
| — | NCT07459322 | Apr 2026 → Apr 2027 expected | obstructive sleep apnea syndrome | Fu Jen Catholic University Hospital | Not yet recruiting | No outcome recorded |
| — | NCT07265050 | Jan 2026 → Dec 2027 expected | — | Seoul National University Hospital | Not yet recruiting | No outcome recorded |
| — | NCT07351474 | Jan → Dec 2026 expected | delirium, gastric cancer | The First Affiliated Hospital with Nanjing Medical University | Not yet recruiting | No outcome recorded |
| — | NCT07335536 | Oct 2025 → Dec 2026 expected | infertility disorder | Diansan Su | Recruiting | No outcome recorded |
| — | NCT07109362 | Aug 2025 → Jun 2026 overdue | glioma | Beijing Tiantan Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06990763 | Jun → Dec 2025 overdue | female reproductive system disorder | Second Hospital of Shanxi Medical University | Not yet recruiting | No outcome recorded |
| — | NCT07050212 | Apr 2025 → Mar 2026 overdue | — | Maternal and Child Health Hospital of Hubei Province | Recruiting | No outcome recorded |
| — | NCT07569614 | Apr 2025 → Feb 2026 | delirium | First Affiliated Hospital of Kunming Medical University | Completed | No outcome recorded |
| — | NCT06775366 | Feb 2025 → Apr 2026 overdue | circadian rhythm sleep disorder, cognitive disorder | The Second Affiliated Hospital of Chongqing Medical University | Not yet recruiting | No outcome recorded |
| — | NCT06716840 | Feb → Apr 2025 overdue | — | First Affiliated Hospital of Zhejiang University | Recruiting | No outcome recorded |
| — | NCT07467603 | Feb → Apr 2025 | — | The First Hospital of Hebei Medical University | Completed | No outcome recorded |
| — | NCT06700681 | Sep 2024 → Dec 2026 expected | vascular hemostatic disease | Taipei Veterans General Hospital, Taiwan | Enrolling by invitation | No outcome recorded |
| — | NCT06332157 | Sep 2024 → Dec 2025 | — | Beijing Chao Yang Hospital | Unknown | No outcome recorded |
| — | NCT06496165 | Jul 2024 → Dec 2026 expected | coronary artery disorder | Shanghai Zhongshan Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06583811 | Jul 2024 → Jan 2025 overdue | — | Egymedicalpedia | Recruiting | No outcome recorded |
| — | NCT06581731 | Jun 2024 → Mar 2026 | — | Nanjing First Hospital, Nanjing Medical University | Completed | No outcome recorded |
| — | NCT06419543 | May → Oct 2024 | — | Tongji Hospital | Completed | No outcome recorded |
| — | NCT06359834 | Apr → Aug 2024 | hepatobiliary disorder | Yonsei University | Completed | No outcome recorded |
| — | NCT06258356 | Feb 2024 → Dec 2028 expected | — | National Taiwan University Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06121609 | Jan → Apr 2024 | — | Tongji Hospital | Completed | No outcome recorded |
| — | NCT06187896 | Jan 2024 → Feb 2026 overdue | obesity disorder | RenJi Hospital | Recruiting | No outcome recorded |
| — | NCT06217055 | Jan → Oct 2024 | urinary bladder cancer | Yonsei University | Unknown | No outcome recorded |
| — | NCT06170918 | Dec 2023 → May 2024 | — | Zhihong LU | Unknown | No outcome recorded |
| — | NCT06093971 | Nov 2023 → Oct 2024 | prostate neoplasm | Yonsei University | Completed | No outcome recorded |
| — | NCT06115031 | Nov 2023 → Nov 2025 | delirium | Samsung Medical Center | Completed | No outcome recorded |
| — | NCT06009055 | Sep 2023 → Nov 2024 | type 2 diabetes mellitus | Zheng Guo | Unknown | No outcome recorded |
| — | NCT05748665 | Aug 2023 → Jan 2024 | — | Xijing Hospital | Completed | No outcome recorded |
| — | NCT05990673 | Aug → Sep 2023 | — | Zhihong LU | Unknown | No outcome recorded |
| — | NCT06004843 | Aug 2023 → Feb 2026 | obesity disorder | RenJi Hospital | Unknown | No outcome recorded |
| — | NCT05935657 | Aug 2023 → Jun 2024 | — | Pusan National University Yangsan Hospital | Unknown | No outcome recorded |
| — | NCT06009991 | Jul 2023 → Sep 2025 | — | Tongji Hospital | Unknown | No outcome recorded |
| — | NCT05538741 | Jul 2023 → Jun 2024 | hypotensive disorder | Kangbuk Samsung Hospital | Completed | No outcome recorded |
| — | NCT05536323 | Jul → Nov 2023 | — | Kangbuk Samsung Hospital | Unknown | No outcome recorded |
| — | NCT05864625 | Jun 2023 → Jun 2025 | aortic valve stenosis | Pusan National University Yangsan Hospital | Completed | No outcome recorded |
| — | NCT05907525 | Jun 2023 → Apr 2024 | — | Pusan National University Yangsan Hospital | Completed | No outcome recorded |
| — | NCT06178848 | Jun → Oct 2023 | acalculous cholecystitis, acute cholecystitis, gallbladder neoplasm | Yonsei University | Completed | No outcome recorded |
| — | NCT06275425 | Jun → Nov 2023 | thyroid tumor | Yonsei University | Completed | No outcome recorded |
| — | NCT07083440 | Jun 2023 → May 2024 | digestive system disorder | Children's Hospital of Hebei Province | Completed | No outcome recorded |
| — | NCT05876793 | Jun 2023 | — | Sichuan Provincial People's Hospital | Completed | No outcome recorded |
| — | NCT05864404 | May 2023 → Oct 2024 | — | Yonsei University | Unknown | No outcome recorded |
| — | NCT05866315 | May → Sep 2023 | — | Wonkwang University Hospital | Completed | No outcome recorded |
| — | NCT05736341 | May 2023 | pregnancy disorder | Yonsei University | Completed | No outcome recorded |
| — | NCT05801757 | May 2023 → Apr 2024 | colonic disorder | Tongji Hospital | Completed | No outcome recorded |
| — | NCT05723627 | Apr → Sep 2023 | — | Yonsei University | Completed | No outcome recorded |
| — | NCT05835713 | Apr 2023 → Apr 2024 | bronchial disorder, tracheal stenosis | Samsung Medical Center | Withdrawn | No outcome recorded |
| — | NCT05774366 | Mar → Dec 2023 | — | Daegu Catholic University Medical Center | Unknown | No outcome recorded |
| — | NCT05891145 | Feb 2023 → Dec 2026 expected | — | Yangzhou University | Recruiting | No outcome recorded |
| — | NCT05686863 | Jan → Jul 2023 | — | Tongji Hospital | Completed | No outcome recorded |
| — | NCT05356091 | Dec 2022 → Feb 2023 | — | Kangbuk Samsung Hospital | Completed | No outcome recorded |
| — | NCT05631028 | Dec 2022 | lung cancer | Shiyou Wei | Completed | No outcome recorded |
| — | NCT05557253 | Oct 2022 → Oct 2023 | — | Seoul National University Hospital | Unknown | No outcome recorded |
| — | NCT05533580 | Oct 2022 → Jan 2023 | gallbladder disorder | Second Affiliated Hospital of Nanchang University | Unknown | No outcome recorded |
| — | NCT05533567 | Oct 2022 → Jan 2023 | gallbladder disorder | Second Affiliated Hospital of Nanchang University | Unknown | No outcome recorded |
| — | NCT05519371 | Oct 2022 | — | Beijing Chao Yang Hospital | Unknown | No outcome recorded |
| — | NCT05527314 | Aug 2022 → Feb 2023 | — | Second Affiliated Hospital of Nanchang University | Completed | No outcome recorded |
| — | NCT05435911 | Aug → Dec 2022 | — | Seoul National University Hospital | Completed | No outcome recorded |
| — | NCT05397886 | Aug 2022 → Apr 2023 | — | Seoul National University Hospital | Completed | No outcome recorded |
| — | NCT05514405 | Aug 2022 → Aug 2026 overdue | osteoarthritis, knee | Inje University | Recruiting | No outcome recorded |
| — | NCT05485064 | Aug → Nov 2022 | — | The Affiliated Hospital of Qingdao University | Completed | No outcome recorded |
| — | NCT05453955 | Aug 2022 → Feb 2023 | vertebral column disorder | Korea University Guro Hospital | Completed | No outcome recorded |
| — | NCT05423951 | Jul 2022 → Nov 2023 | — | Seoul National University Hospital | Completed | No outcome recorded |
| — | NCT06180876 | Jul 2022 → Jan 2024 | — | Zhihong LU | Completed | No outcome recorded |
| — | NCT05396690 | Jun 2022 → May 2023 | — | Ajou University School of Medicine | Unknown | No outcome recorded |
| — | NCT05375747 | Jun 2022 → Jan 2023 | hypotensive disorder | Seoul National University Hospital | Withdrawn | No outcome recorded |
| — | NCT05322902 | Jun 2022 → Jul 2023 | osteoarthritis, knee | Gangnam Severance Hospital | Completed | No outcome recorded |
| — | NCT05305248 | Apr → Sep 2022 | — | Gangnam Severance Hospital | Completed | No outcome recorded |
| — | NCT05350085 | Apr 2022 → Apr 2023 | anterograde amnesia | Peking Union Medical College Hospital | Unknown | No outcome recorded |
| — | NCT05439057 | Apr 2022 → Oct 2024 | — | Inje University | Completed | No outcome recorded |
| — | NCT05160987 | Mar 2022 → Nov 2027 expected | — | Zhujiang Hospital | Recruiting | No outcome recorded |
| — | NCT05280236 | Mar 2022 → Apr 2024 | — | Yonsei University | Completed | No outcome recorded |
| — | NCT05357430 | Mar 2022 → Apr 2023 | — | Yangzhou University | Completed | No outcome recorded |
| — | NCT05298228 | Mar 2022 → Jul 2023 | — | Yonsei University | Unknown | No outcome recorded |
| — | NCT05164146 | Feb → Aug 2022 | — | Yonsei University | Completed | No outcome recorded |
| — | NCT05164159 | Feb → Aug 2022 | acute cholecystitis | Yonsei University | Completed | No outcome recorded |
| — | NCT05201300 | Feb → Nov 2022 | — | Ajou University School of Medicine | Completed | No outcome recorded |
| — | NCT05574257 | Feb → May 2022 | female reproductive system disorder, urinary system disorder | Wonkwang University Hospital | Completed | No outcome recorded |
| — | NCT05047939 | Dec 2021 → Aug 2022 | — | Seoul National University Hospital | Completed | No outcome recorded |
| — | NCT05103696 | Oct 2021 → Dec 2022 | — | Peking University People's Hospital | Completed | No outcome recorded |
| — | NCT05053763 | Sep 2021 → Dec 2022 | — | Jianbo Yu | Unknown | No outcome recorded |
| — | NCT05437497 | Aug 2021 → Dec 2022 | — | The Third Xiangya Hospital of Central South University | Unknown | No outcome recorded |
| — | NCT04968054 | Jul 2021 → May 2023 | ossification of the posterior longitudinal ligament of the spine, spondylosis, cervical | Gangnam Severance Hospital | Completed | No outcome recorded |
| — | NCT04950621 | Jul 2021 → Jun 2022 | cerebrovascular disorder | Air Force Military Medical University, China | Completed | No outcome recorded |
| — | NCT04656964 | Apr 2021 → Dec 2022 | — | Peking University People's Hospital | Completed | No outcome recorded |
| — | NCT04727034 | Mar 2021 → Jul 2023 | gastric cancer | RenJi Hospital | Unknown | No outcome recorded |
| — | NCT04658173 | Dec 2020 → Oct 2022 | — | Tianjin Nankai Hospital | Unknown | No outcome recorded |
| — | NCT04601350 | Nov 2020 → May 2022 | — | Yangzhou University | Completed | No outcome recorded |
Also used as a comparator or background therapy in 31 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT06231563 Comparator | Mar 2026 → Sep 2029 expected | Parkinson disease | VA Office of Research and Development | Recruiting | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT07113483 Comparator | Oct 2025 → Jan 2026 overdue | — | Romanian Society for Enteral and Parenteral Nutrition | Recruiting | No outcome recorded |
| Phase 3 | NCT04901871 Comparator | May → Jul 2021 | — | Gangnam Severance Hospital | Completed | No outcome recorded |
| Phase 413 trials | ||||||
| Phase 4 | NCT07675850 Comparator | Jul 2026 → Apr 2027 expected | — | Seoul National University Hospital | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07347496 Comparator | Mar 2026 → May 2028 expected | — | The First Affiliated Hospital of Xinxiang Medical College | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07277881 Background | Jan 2026 → Oct 2027 expected | delirium | Medical University of Gdansk | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07213544 Comparator | Nov 2025 → Jan 2027 expected | — | Medical University of South Carolina | Recruiting | No outcome recorded |
| Phase 4 | NCT07161297 Comparator | Sep 2025 overdue | inflammatory bowel disease | Humanitas Clinical and Research Center | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07362173 Comparator | Mar 2025 → May 2026 overdue | chronic obstructive pulmonary disease, multiple organ dysfunction syndrome | Iuliu Hatieganu University of Medicine and Pharmacy | Active not recruiting | No outcome recorded |
| Phase 4 | NCT07076628 Comparator | Aug 2023 → May 2025 | respiratory failure | DongGuk University | Completed | No outcome recorded |
| Phase 4 | NCT05688345 Comparator | Feb → Aug 2023 | — | Asan Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT05651399 Comparator | Dec 2022 → Jun 2023 | — | Asan Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT06095570 Comparator | Jul 2022 → Dec 2023 | — | The Second Affiliated Hospital of Hainan Medical University | Unknown | No outcome recorded |
| Phase 4 | NCT05447507 Comparator | Jul → Oct 2022 | musculoskeletal system disorder | Seoul National University Hospital | Completed | No outcome recorded |
| Phase 4 | NCT05468996 Comparator | May → Oct 2022 | — | Asan Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT05994547 Comparator | Apr 2022 → Jun 2023 | — | Chungbuk National University Hospital | Completed | No outcome recorded |
| Phase not applicable15 trials | ||||||
| — | NCT07707258 Background | Jul → Sep 2026 expected | — | Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine | Not yet recruiting | No outcome recorded |
| — | NCT07192549 Background | Sep 2025 → Sep 2030 expected | delirium | General Hospital of Ningxia Medical University | Not yet recruiting | No outcome recorded |
| — | NCT07035301 Background | Mar → Jul 2025 | respiratory system disorder | Harbin Medical University | Completed | No outcome recorded |
| — | NCT07002801 Background | Mar 2025 → Jun 2026 overdue | digestive system disorder | Harbin Medical University | Recruiting | No outcome recorded |
| — | NCT06755996 Background | Jan → Aug 2025 | — | Tongji Hospital | Completed | No outcome recorded |
| — | NCT06531915 Comparator | Dec 2024 | — | Anhui Provincial Hospital | Unknown | No outcome recorded |
| — | NCT06284668 Comparator | Mar 2024 → May 2025 | sleep disorder | Tianjin Medical University General Hospital | Completed | No outcome recorded |
| — | NCT06108830 Comparator | Dec 2023 → Nov 2024 overdue | sleep disorder | Tianjin Medical University General Hospital | Recruiting | No outcome recorded |
| — | NCT06385002 Comparator | Jul 2023 → Aug 2024 | — | Pusan National University Yangsan Hospital | Completed | No outcome recorded |
| — | NCT05785234 Background | Apr 2023 → Mar 2025 | gastric neoplasm | Yonsei University | Unknown | No outcome recorded |
| — | NCT05434494 Comparator | Jul 2022 → Jul 2023 | — | Ajou University School of Medicine | Unknown | No outcome recorded |
| — | NCT04994704 Comparator | Dec 2021 → Jul 2023 | — | Gangnam Severance Hospital | Completed | No outcome recorded |
| — | NCT05019222 Comparator | Sep 2021 → Aug 2022 | atlanto-axial fusion | Gangnam Severance Hospital | Completed | No outcome recorded |
| — | NCT05016518 Comparator | Sep 2021 → May 2022 | thyroid tumor | Gangnam Severance Hospital | Completed | No outcome recorded |
| — | NCT04983966 Comparator | Aug 2021 → Feb 2024 | — | Gangnam Severance Hospital | Completed | No outcome recorded |
Evidence & citations 27 cited values
Every value below carries the sentence it was read from. 251 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Remimazolam | “individualized, Eleveld pharmacokinetic/pharmacodynamic model-guided dosing strategy for remimazolam in adult patients undergoing elective non-cardiac surgery under general anesthesia.” NCT07675850 ↗222“This is a single-center, prospective, randomized, controlled pilot study using remimazolam and propofol for sedation in mechanically ventilated ICU patients.” NCT04790734 ↗ “As a novel ultra-short-acting benzodiazepines drugs, Remimazolam has been accepted for induction and maintenance of clinical anesthesia.” NCT05624424 ↗ “Remimazolam is a new type of benzodiazepine drug that can be safely used for the induction and maintenance of general anesthesia” NCT05631028 ↗ “Remimazolam is a new rapid offset benzodiazepine used for procedural sedation and general anaesthesia.” PMID 35562226 ↗ May 2022 “Anesthesia was induced by sequential intravenous injection of remimazolam, sufentanil, and rocuronium.” NCT07192549 ↗ “all subjects were administered remimazolam via a TCI pump until they reached a state of mild sedation” NCT07109362 ↗ “Remimazolam is a new benzodiazepine for procedural sedation and general anaesthesia.” PMID 34246461 ↗ Jul 2021 “Remimazolam besylate is a newly marketed ultra-short-acting GABAa receptor agonist” NCT05758597 ↗ “Group B: Remimazolam Group” NCT06583811 ↗ “A. Remimazolam (CNS 7056)” NCT01145222 ↗ |
| Known as | Anerem | “Remimazolam (Anerem® in Japan; ByFavo™ in the USA; Aptimyda™ in the EU) is an ultra-short-acting intravenous (IV) benzodiazepine sedative/anesthetic being developed by PAION AG...” PMID 32274703 ↗ Apr 2020 |
| Known as | Aptimyda | “Remimazolam (Anerem® in Japan; ByFavo™ in the USA; Aptimyda™ in the EU) is an ultra-short-acting intravenous (IV) benzodiazepine sedative/anesthetic being developed by PAION AG...” PMID 32274703 ↗ Apr 2020 |
| Known as | BIPRAZINE PF | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | Byfavo | “Remimazolam (Anerem® in Japan; ByFavo™ in the USA; Aptimyda™ in the EU) is an ultra-short-acting intravenous (IV) benzodiazepine sedative/anesthetic being developed by PAION AG...” PMID 32274703 ↗ Apr 202014“Remimazolam (Byfavo) is a novel benzodiazepine approved by the U.S. Food and Drug Administration in July 2020 for sedation in patients undergoing procedures less than 30...” NCT07325227 ↗ “Exploring the Use of Remimazolam (BYFAVO®) in Patients at High Risk for ERCP to Reduce Intraoperative Hypotension and Assess Safety and Efficacy: A Randomized Controlled Trial” NCT06258356 ↗ “REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]” NCT05423951 ↗ “Byfavo 20 mg powder for solution for injection, remimazolam.” NCT06614036 ↗ “Remimazolam 20 MG Injection [Byfavo]” NCT07704437 ↗ “Remimazolam 20 MG Injection [Byfavo]” NCT06398275 ↗ “Remimazolam Injection [Byfavo]” NCT05041725 ↗ “Remimazolam Injection [Byfavo]” NCT05396690 ↗ “Drug: Remimazolam (Byfavo)” NCT05514405 ↗ “Remimazolam (Byfavo)” NCT07620782 ↗ “Remimazolam (Byfavo)” NCT07674719 ↗ |
| Known as | CNS 7056 | “A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety,...” PMID 22190555 ↗ Dec 20113“A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy.” PMID 29723512 ↗ Apr 2018 “A. Remimazolam (CNS 7056)” NCT01145222 ↗ |
| Known as | CNS 7056 besylate | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | CNS 7056B | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | CNS 70754 | “The goal of this clinical trial is to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of remimazolam (CNS 70754) in healthy adult participants.” NCT07045467 ↗ |
| Known as | GW-502056X | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | HR7056 | “HR7056 is a new benzodiazepine, showing more faster acting onset and recovery than currently available short-acting sedatives.” PMID 30510509 ↗ Nov 20181“PURPOSE: Remimazolam tosylate (HR-7056) is a novel ester-type benzodiazepine with ultrafast onset of effect.” PMID 32178858 ↗ Mar 2020 |
| Known as | ONO-2745 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | ONO-2745BS | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | ONO-IN-251 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | Remimazolam (CNS 7056) | “Remimazolam (CNS 7056)” NCT04611425 ↗ |
| Known as | Remimazolam besilate | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | remimazolam besylate | “Remimazolam besylate (RB), as a new benzodiazepine sedative agent, has been approved in clinical anesthesia with prominent characteristics of short onset/offset, less...” NCT06717945 ↗24“Remimazolam Besylate is a 1.1 class new drug that acts on GABA receptors and is metabolized by plasma esterase with fast metabolism time, only 1/7 of midazolam, which may be...” NCT05103696 ↗ “Remimazolam besylate is a new type of water-soluble ultra short acting benzodiazepine drug that is hydrolyzed and metabolized by plasma esterase in the body, independent of...” NCT06061159 ↗ “Remimazolam besylate is a novel, ultra-short-acting benzodiazepine that undergoes organ-independent metabolism by tissue esterases into an inactive metabolite.” NCT06496165 ↗ “Remimazolam besylate is a novel ultra-short-acting benzodiazepine that can potentially be a safe and effective sedative in intensive care units.” PMID 37576823 ↗ Jul 2023 “Remimazolam besylate, as a novel anesthetic drug, has not yet had its advantages in thoracoscopic surgery in elderly patients fully clarified.” NCT07086911 ↗ “Remimazolam Besylate (Trade name: Rymazol®), supplied as a lyophilized powder (25 mg/vial) reconstituted with sterile water.” NCT07045467 ↗ “Participants in the remimazolam group will be intravenously injected with 0.1 mg/kg of remimazolam besylate” NCT06531915 ↗ “After regional anesthesia, remimazolam besylate was administered at the assigned dose.” PMID 38378937 ↗ Feb 2024 “Remimazolam besylate is a newly marketed ultra-short-acting GABAa receptor agonist” NCT05758597 ↗ “Remimazolam besylate and low-dose Esketamine” NCT06303037 ↗ “Drug: Remimazolam besylate” NCT05975255 ↗ “Drug: Remimazolam Besylate” NCT05453955 ↗ “Drug: Remimazolam Besylate” NCT05606315 ↗ “Drug: Remimazolam besylate” NCT07213544 ↗ “Drug: Remimazolam besylate” NCT05723627 ↗ “Drug: Remimazolam besylate” NCT06153498 ↗ “Remimazolam besylate TIVA” NCT05486377 ↗ |
| Known as | Remimazolam Tosilate | “A Multi-center, Randomized, Double-blind Clinical Study to Evaluate the Efficacy and Safety of Remimazolam Tosilate (Ruibeining®) for Injection for Sedation in Non-intubated...” NCT06216444 ↗13“The purpose of this study is to evaluate the efficacy and safety of Remimazolam Tosilate for Injection for sedation in Upper Gastrointestinal Endoscopy” NCT06169995 ↗ “To evaluate the efficacy and safety of Remimazolam Tosilate for injection in local anesthesia assisted sedation” NCT05015361 ↗ “Remimazolam tosilate, an ultra-short-acting benzodiazepine, offers a promising safety profile” NCT07467603 ↗ “Remimazolam tosilate (RT) is a new short-acting GABA(A) receptor agonist” PMID 32677707 ↗ Jul 2020 “Remimazolam Tosilate for Injection 0.1mg/kg at induction” NCT04908553 ↗ “IV Remimazolam tosilate 0.3mg/kg” NCT05255211 ↗ “Drug: Remimazolam Tosilate” NCT07035301 ↗ “Drug: Remimazolam Tosilate” NCT06222294 ↗ “Drug: Remimazolam Tosilate” NCT03921775 ↗ |
| Known as | remimazolam tosylate | “Remimazolam tosylate, a novel benzodiazepine with rapid onset and short duration, metabolized by tissue esterases, represents a promising agent for ICU sedation.” PMID 42164575 ↗ Mar 20264“IV bolus of Remimazolam Tosylate with a loading dose of 0.4mg/kg body weight over 1 minute followed by a maintenance dose of 1.5mg/kg/h over 2 hours.” NCT03444480 ↗ “Single IV bolus of Remimazolam Tosylate over 1 minute at 0.01 mg/kg body weight” NCT01970072 ↗ “Remimazolam tosylate, a novel short-acting benzodiazepine” PMID 41855428 ↗ Mar 2026 “Remimazolam tosylate is a novel benzodiazepine drug” NCT05876793 ↗ |
| Known as | RF-10007 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Known as | Ruibeining | “A Multi-center, Randomized, Double-blind Clinical Study to Evaluate the Efficacy and Safety of Remimazolam Tosilate (Ruibeining®) for Injection for Sedation in Non-intubated...” NCT06216444 ↗ |
| Known as | Ruima | “this clinical study was initiated by Yichang Humanwell Pharmaceutical Co., Ltd. to obtain approval from the Center for Drug Evaluation (CDE) of the National Medical Products...” PMID 41915173 ↗ Mar 2026 |
| Known as | Rymazol | “Remimazolam Besylate (Trade name: Rymazol®), supplied as a lyophilized powder (25 mg/vial) reconstituted with sterile water.” NCT07045467 ↗ |
| Known as | SP148.5 | ChEMBL registry synonym — accepted as the source's own label CHEMBL4297526 ↗ |
| Action | Activate | “Remimazolam is a recently developed ultra-short agonist acting at the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)A receptor.” NCT05201300 ↗ |
| Modality | Small molecule | “Remimazolam is an ultra-short-acting benzodiazepine” PMID 26363333 ↗ Sep 2015 |
| Route | Intravenous | “Patients received their assigned treatment administered as a single intravenous injection by a syringe driver over 1 minute” NCT00869440 ↗ |