Effect of Remimazolam and Propofol on Hemodynamic Stability During Anesthesia Induction in OPCAB Patients

Completed 106 enrolled Seoul National University Hospital

RandomizedParallel-groupDouble-blindPrevention

Summary

Remimazolam is a novel ultra-short-acting benzodiazepine. Several studies demonstrated that its efficacy as a sedative hypnotics for general anesthesia is non-inferior to propofol. However, evidence on the hemodynamic stability of remimazolam for the anesthesia induction in patients undergoing coronary artery bypass grafting is lacking. This prospective randomized trial aims to compare hemodynamic stability during anesthesia induction between remimazolam and propofol in patients undergoing coronary artery bypass grafting.

Timeline

Start: 2022-07-26
Primary completion: 2023-11-08
Completion: 2023-11-08

Publications

Ju JW, Lee DJ, Chung J, Lee S, Cho YJ, Jeon Y, Nam K. Effect of remimazolam versus propofol on hypotension after anesthetic induction in patients undergoing coronary artery bypass grafting: A randomized controlled trial. J Clin Anesth. 2024 Nov;98:111580. doi: 10.1016/j.jclinane.2024.111580. Epub 2024 Aug 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Propofol	Small molecule	1.5 mg/kg	—
Subject	Remimazolam	Small molecule	1 mg/kg	Intravenous
Background	Rocuronium	Other / unclassified	1 mg/kg	Intravenous
Background	Sufentanil	Other / unclassified	0.5 ug/kg	Intravenous
Background	Sufentanil	Other / unclassified	2 ug/kg	Intravenous

Indications

No indication recorded.