drugset

drugset / Trial / NCT05555667

Long-term Sedation With Remimazolam Besylate in Critically Ill Patients

NCT05555667 ↗

Phase 3 Unknown 728 enrolled Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

RandomizedParallel-groupSingle-blindTreatment

Summary

A randomized non-inferior trial comparing remimazolam besylate with propofol for long-term sedation during invasive mechanical ventilation in critically ill patients

Timeline

Start: 2023-05-16
Primary completion: 2025-11-01
Completion: 2025-12-01

Publications

Yang X, Tang Y, Du R, Yu Y, Xu J, Zhang J, Liu H, Zou X, Ren L, Yuan S, Shang Y. Long-term sedation with remimazolam besylate versus propofol in critically ill patients during invasive mechanical ventilation: a study protocol for a multicenter randomized non-inferior trial. Front Pharmacol. 2023 Jul 28;14:1139872. doi: 10.3389/fphar.2023.1139872. eCollection 2023.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Propofol	Small molecule	2 mg/kg	Intravenous
Comparator	Propofol	Small molecule	4 mg/kg	Intravenous
Subject	Remimazolam	Small molecule	0.15 mg/kg	—
Subject	Remimazolam	Small molecule	0.3 mg/kg	—

Indications

No indication recorded.