Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol

Completed 66 enrolled Seoul National University Hospital

RandomizedParallel-groupTriple-blindTreatment

Summary

This prospective randomized trial aims to compare recovery time from discontinuation of remimazolam followed by flumazenil administration vs. propofol-based total intravenous anesthesia in patients undergoing breast cancer surgery.

Timeline

Start: 2022-08-02
Primary completion: 2022-12-21
Completion: 2022-12-21

Outcome

Met primary endpoint

paper The remimazolam group had a significantly shorter mean time to eye opening than the propofol group [127 ± 51 vs. 314 ± 140 s; mean difference 187 s PMID 38205822 ↗

Publications

Lee J, Kim DH, Ju JW, Nam K, Cho YJ, Jeon Y, Lee S. Comparison of recovery profiles between total intravenous anaesthesia with propofol or remimazolam reversed with flumazenil in patients undergoing breast surgery: A randomised controlled trial. Eur J Anaesthesiol. 2024 Mar 1;41(3):199-207. doi: 10.1097/EJA.0000000000001951. Epub 2024 Jan 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Flumazenil	Small molecule	—	—
Comparator	Propofol	Small molecule	—	Intravenous
Subject	Remimazolam	Small molecule	2.5 mg	Intravenous

Indications

No indication recorded.