Remimazolam Bolus for General Anesthesia

Phase 3 Completed 120 enrolled Gangnam Severance Hospital

RandomizedFactorialTriple-blindOther

Summary

It is important to estimate the adequate dose of remimazolam intravenous bolus injection to induce the loss of consciousness. We will determine the ED50 and ED95 of remimazolam intravenous bolus on the loss of consciousness in patients undergoing general anesthesia.

Timeline

Start: 2021-05-27
Primary completion: 2021-07-20
Completion: 2021-07-26

Publications

Chae D, Kim HC, Song Y, Choi YS, Han DW. Pharmacodynamic analysis of intravenous bolus remimazolam for loss of consciousness in patients undergoing general anaesthesia: a randomised, prospective, double-blind study. Br J Anaesth. 2022 Jul;129(1):49-57. doi: 10.1016/j.bja.2022.02.040. Epub 2022 May 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Remimazolam	Small molecule	0.02 mg/kg	Intravenous
Comparator	Remimazolam	Small molecule	0.07 mg/kg	Intravenous
Comparator	Remimazolam	Small molecule	0.12 mg/kg	Intravenous
Comparator	Remimazolam	Small molecule	0.17 mg/kg	Intravenous
Comparator	Remimazolam	Small molecule	0.22 mg/kg	Intravenous
Comparator	Remimazolam	Small molecule	0.27 mg/kg	Intravenous

Indications

No indication recorded.