Effect of Remazolam on Hemodynamics During Hepatectomy

Phase 4 Completed 70 enrolled Jun Zhang

RandomizedParallel-groupDouble-blindPrevention

Summary

There is high incidence of hemodynamic instability in patients undergoing hepatectomy with low central venous pressure, especially in general anesthesia combined with epidural anesthesia. Remazolam, a new benzodiazepine, has no significant cardiovascular inhibitory effect. Investigators hypothesis that remazolam will provide better hemodynamic when compared with propofol in patients undergoing hepatectomy with general anesthesia combined with epidural anesthesia.

Timeline

Start: 2024-08-23
Primary completion: 2024-10-30
Completion: 2024-11-08

Publications

Qian Y, Hou W, Yang L, Chen N, Zhang J. A randomized trial evaluating hemodynamics during minor hepatectomy under general anesthesia combined with thoracic epidural anesthesia: remimazolam versus propofol. BMC Anesthesiol. 2025 Aug 20;25(1):413. doi: 10.1186/s12871-025-03290-w.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	2 mg/kg	Intravenous
Subject	Remimazolam	Small molecule	0.3 mg/kg	Intravenous

Indications

No indication recorded.