Comparison of Remifentanil With a Combination of Remimazolam and Dexmedetomidine for Awake Tracheal Intubation

Completed 64 enrolled Nanjing First Hospital, Nanjing Medical University

RandomizedParallel-groupSingle-blindPrevention

Summary

Awake fiberoptic intubation (AFOI) requires airway surface anesthesia to inhibit pharyngeal reflex, glottis closure reflex, and cough reflex. Additionally, the use of sedative drugs can enhance patient comfort and tolerance, reduce anxiety, and eliminate harmful effects on systemic hemodynamics.The objective of this study is to compare the safety and efficacy of remifentanil alone versus a combination of dexmedetomidine and remifentanil for sedation during conscious tracheal intubation.

Timeline

Start: 2024-06-14
Primary completion: 2026-03-04
Completion: 2026-03-04

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.5 ug/kg	Intravenous
Subject	Remimazolam	Small molecule	0.5 mg/kg	—
Background	Remifentanil	Small molecule	0.1 ug/kg	—

Indications

No indication recorded.