Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children

Completed 106 enrolled Tongji Hospital

RandomizedParallel-groupTriple-blindTreatment

Summary

To observe the sedative effect and safety of remiazolam combined with small dose of esketamine in painless bidirectional endoscopy in children, and to provide a more reasonable and safe sedative and analgesic regimen for children's gastrointestinal endoscopy.

Timeline

Start: 2023-01-18
Primary completion: 2023-07-07
Completion: 2023-07-07

Publications

Chu T, Zhou S, Wan Y, Liu Q, Xin Y, Tian Z, Yan T, Xu A. Comparison of remimazolam and propofol combined with low dose esketamine for pediatric same-day painless bidirectional endoscopy: a randomized, controlled clinical trial. Front Pharmacol. 2024 Feb 5;15:1298409. doi: 10.3389/fphar.2024.1298409. eCollection 2024.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Propofol	Small molecule	5 mg/kg	Intravenous
Comparator	Propofol	Small molecule	10 mg/kg	Intravenous
Subject	Remimazolam	Small molecule	1 mg/kg	Intravenous
Subject	Remimazolam	Small molecule	3 mg/kg	Intravenous
Background	Esketamine	Other / unclassified	0.25 mg/kg	Intravenous
Background	Remifentanil	Small molecule	0.5 ug/kg	—
Background	Remifentanil	Small molecule	1 ug/kg	—

Indications

No indication recorded.