drugset / Trial / NCT06775366
The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function
RandomizedParallel-groupDouble-blindPrevention
Summary
This study want to observe the effects of remimazolam and propofol for general anesthesia on postoperative rhythm and cognitive function. The observation group was given remimazolam for general anesthesia, and the control group was given propofol for general anesthesia. Both drugs are commonly used as intravenous anesthetics for general anesthesia and have been shown to be safe for use in general anesthesia. The investigators hope can understand the effects of remimazolam and propofol for general anesthesia on rhythm status and cognitive function through this study, further reduce the occurrence of postoperative cognitive function impairment, and enable subjects to better recover.
Timeline
- Start
- 2025-02-24
- Primary completion
- 2026-04-30
- Completion
- 2026-05-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 4 mg/kg | Intravenous |
| Comparator | Propofol | Small molecule | 10 mg/kg | Intravenous |
| Subject | Remimazolam | Small molecule | 1 mg/kg | Intravenous |
| Background | Rocuronium | Other / unclassified | 0.6 mg/kg | Intravenous |
| Background | Sevoflurane | Other / unclassified | — | — |
| Background | Sufentanil | Other / unclassified | 0.5 ug/kg | Intravenous |