drugset / Trial / NCT04656964
Comparison Between Remimazolam Tosilate and Midazolam in Elderly Patients Undergoing Gastrointestinal Endoscopy
Completed
353 enrolled
Peking University People's Hospital
Emergency General Hospital · collabFenyang Hospital Affiliated to Shanxi Medical University · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Midazolam is a commonly used drug in gastrointestinal endoscopy due to the good cardiovascular stability and mild respiratory depression for elderly patients. However, there is the concern about the the longer and less predictable recovery or the potential for repeat sedation when the active metabolite becomes bioavailable. Remimazolam Tosilate is an innovative benzodiazepine with better sedation effect and less recovery or resedation issues than midazolam, which possibly make the drug more suitable in elderly patients. We aim to clarify whether remimazolam tosilate is better than midazolam in elderly patients undergoing gastrointestinal endoscopy.
Timeline
- Start
- 2021-04-01
- Primary completion
- 2022-12-31
- Completion
- 2022-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Midazolam | Small molecule | 0.015 mg/kg | — |
| Subject | Remimazolam | Small molecule | 2.5 mg | — |
Indications
No indication recorded.