drugset / Trial / NCT06583811

Remifentanil and Remimazolam to Limit Patient Movement

NCT06583811

RandomizedParallel-groupOpen-labelDiagnostic

Summary

Local anesthetics (LA) may be administered by injection (retrobulbar, peribulbar, subconjunctival, lid, or facial block) or by instillation (topical anesthesia), Considerable drawbacks of local anesthesia in these patients include the fact that a few patients can remain comfortable on an operating table for procedures that exceed two or three hours. Sedation may be helpful with LA to decrease the experience of discomfort, movement and anxiety, which may in turn positively influence hemodynamic parameters, patient satisfaction, and overall improve surgical safety. Sedatives used in eye surgeries include benzodiazepines, opioids, alpha-adrenoceptor agonists, and propofol.

Timeline

Start
2024-07-10
Primary completion
2025-01-01
Completion
2025-01-10

Drugs

EvaluationDrugModalityDoseRoute
Comparator Remifentanil Small molecule 0.03 ug/kg
Comparator Remifentanil Small molecule 0.05 ug/kg
Subject Remimazolam Small molecule 0.3 ug/kg
Subject Remimazolam Small molecule 0.5 ug/kg

Indications

No indication recorded.