drugset / Trial / NCT05160987
Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam
Recruiting
440 enrolled
Zhujiang Hospital
Affiliated Hospital of Guangdong Medical University · collabFirst Affiliated Hospital of Shantou University Medical College · collabGuangdong Province Traditional Medical hospital · collabIntegrated traditional Chinese and Western Medicine Hospital of Southern Medical University · collabThe Third Affiliated Hospital of Guangzhou Medical University · collabYunfu People's Hospital · collabZhongshan Hospital Of Traditional Chinese Medicine · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
In this parallel, multicenter, single-blind randomized controlled trial, mechanical ventilated patients will be randomly assigned to two groups. One receives remimazolam to achieve sedation goals, while the other receives Midazolam. The primary outcome is the effect of remimazolam on duration of mechanical ventilated of critical patients compared to midazolam.
Timeline
- Start
- 2022-03-29
- Primary completion
- 2027-11-30
- Completion
- 2027-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Midazolam | Small molecule | 0.02 mg/kg | — |
| Comparator | Midazolam | Small molecule | 0.1 mg/kg | — |
| Subject | Remimazolam | Small molecule | 0.1 mg/kg | — |
| Subject | Remimazolam | Small molecule | 0.25 mg/kg | — |
Indications
No indication recorded.