NCT05429086: Explore the Advantages of Remimazolam Used on Gastroscopy

Summary

There are many different types of intravenous anesthetics used in gastroscopy, but each type of drug has its advantages and disadvantages,remimazolam is a novel ultra-short-acting benzodiazepine with rapid onset and recovery, low circulatory depression, and rapid reversal of sedation by flumazenil,remimazolam may be another relatively ideal sedative-hypnotic option for anesthesiologists and gastrointestinal endoscopists. The purpose of this study was to explore whether remimazolam combined with propofol is safer and more effective than remimazolam alone or propofol alone in gastrointestinal endoscopy.

Timeline

Start: 2022-06
Primary completion: 2022-08
Completion: 2022-08

Outcome

Met primary endpoint

paper three groups of pairwise comparisons showed statistical differences, with P< 0.001. PMID 37535618 ↗

Publications

Wei A, Ma S, Dou Y, Wang X, Wu J, Zhou S, Deng Y, Liu X, Li D, Yang M. The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial. PLoS One. 2023 Aug 3;18(8):e0282930. doi: 10.1371/journal.pone.0282930. eCollection 2023.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	0.5 mg/kg	Intravenous
Subject	Remimazolam	Small molecule	2.5 mg	Intravenous

Indications

No indication recorded.