Varied Remimazolam Dosages for Pediatric Endoscopy

Summary

This prospective, randomized, comparative study aims to compare the efficacy and safety of three different doses of remimazolam (0.2 mg/kg, 0.3 mg/kg, and 0.4 mg/kg) combined with sufentanil and propofol for painless gastroscopy in pediatric patients. The study will assess sedation quality, propofol consumption, hemodynamic stability, and adverse event profiles to identify an optimal remimazolam dosing regimen.

Timeline

Start

2023-06-01

Primary completion

2024-05-01

Completion

2024-05-01

Publications

• Chen W, Shi L, Bao W, Liu Y, Shi J. Optimal remimazolam dosage for pediatric painless gastrointestinal endoscopy: a randomized controlled trial comparing efficacy and safety of three doses combined with sufentanil and propofol. BMC Anesthesiol. 2026 Jan 2;26(1):80. doi: 10.1186/s12871-025-03511-2.

Drugs

Indications