Comparison of Remimazolam and Propofol Effect on Oxygen Reserve During Endoscopic Retrograde Cholangiopancreatography

Summary

Propofol is one of the most commonly used sedative in endoscopic procedures, while its potency to induce respiratory depression may threaten patient safety. Remimazolam is known to less likely induce hemodynamic instability when compared to propofol, yet its favorable effects are not clearly evaluated in endoscopic procedures. Hence, this study aimed to compare hemodynamic effects of remimazolam and propofol, by evaluating oxygen reserve index (ORI) in patients scheduled for endoscopic retrograde cholangiopancreatography.

Timeline

Start

2024-04-11

Primary completion

2024-08-29

Completion

2024-08-29

Publications

• Kim JH, Lee K, Lee SJ, Leem G, Lee HS, Park JY, Bang S, Park SW, Kim N, Chung MJ. Remimazolam Preserves Oxygen Reserve and Improves Sedation Safety Compared to Propofol in Endoscopic Retrograde Cholangiopancreatography. United European Gastroenterol J. 2025 Nov;13(9):1730-1739. doi: 10.1002/ueg2.70105. Epub 2025 Sep 5.

Drugs

Indications