NCT07838948: Nalbuphine With Remimazolam Versus Nalbuphine With Propofol for Knee Arthroscopy

Summary

This study compared two combinations of medicines used for sedation and pain relief in adults undergoing knee arthroscopy for knee joint injuries. One group received nalbuphine with remimazolam, and the other received nalbuphine with propofol. The study examined pain, sedation, cognitive function, and adverse events. A total of 100 adults aged 18 to 65 years were randomly assigned to the two groups, with 50 participants in each group. All participants underwent surgery under combined spinal-epidural anesthesia. Pain, sedation, and cognitive function were assessed immediately after surgery and at 6, 12, and 24 hours after surgery.

Timeline

Start: 2025-04-10
Primary completion: 2025-10-02
Completion: 2025-10-02

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Propofol	Small molecule	1.5 mg/kg	Intravenous
Comparator	Propofol	Small molecule	2 mg/kg	Intravenous
Subject	Remimazolam	Small molecule	0.2 mg/kg	Intravenous
Subject	Remimazolam	Small molecule	0.3 mg/kg	Intravenous
Background	Nalbuphine	Small molecule	0.1 mg/kg	Intravenous

Indications

No indication recorded.