drugset / Trial / NCT03034096
General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial
RandomizedParallel-groupDouble-blindTreatment
Summary
This is a large pragmatic multicenter trial comparing maintenance of general anesthesia with total intravenous anesthesia using propofol versus volatile agent (sevoflurane, isoflurane, or desflurane) during cancer surgery. The primary endpoint is all-cause mortality.
Timeline
- Start
- 2017-01-31
- Primary completion
- 2024-09-30
- Completion
- 2024-09-30
Publications
- Bennett-Guerrero E, Romeiser JL, DeMaria S, Nadler JW, Quinn TD, Ponnappan SK, Wang R, Gloff MS, Lee KJ, Levin MA, Sroka RD, Stanley SL, Wang D, Sasson AR; GA-CARES Trial Group. Anesthesia Type during Cancer Surgery: Results of the GA-CARES Randomized, Multicenter Trial. Anesthesiology. 2026 Jan 1;144(1):51-62. doi: 10.1097/ALN.0000000000005769. Epub 2025 Dec 9.
- Bennett-Guerrero E, Romeiser JL, DeMaria S, Nadler JW, Quinn TD, Ponnappan SK, Yang J, Sasson AR. General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description. Perioper Med (Lond). 2023 Jan 11;12(1):2. doi: 10.1186/s13741-022-00290-z.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Desflurane | Other / unclassified | — | Inhaled |
| Subject | Isoflurane | Other / unclassified | — | Inhaled |
| Subject | Propofol | Small molecule | — | Intravenous |
| Subject | Sevoflurane | Other / unclassified | — | Inhaled |
Indications
No indication recorded.