drugset / Trial / NCT07123870
Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns.
RandomizedParallel-groupDouble-blindTreatment
Summary
This study was planned as a single-center, prospective, randomized trial. Adult patients undergoing elective spinal surgery lasting longer than three hours, performed in a neurosurgery operating room, will be evaluated. Patients managed with three different anesthesia methods currently used will be examined for recovery patterns: 1. Total intravenous anesthesia (TIVA), 2. TIVA Combined anesthesia with sevoflurane and intravenous agents (sevoflurane-CIVIA), 3. TIVA Combined anesthesia with desflurane and intravenous agents (desflurane-CIVIA). Recovery patterns include; extubation time, eye opening time, emergence agitation, postoperative nausia and vomiting and postoperative recovery unit discharge time.
Timeline
- Start
- 2025-07-23
- Primary completion
- 2025-10-29
- Completion
- 2025-11-15
Publications
- Background Wolf A, Selpien H, Haberl H, Unterberg M. Does a combined intravenous-volatile anesthesia offer advantages compared to an intravenous or volatile anesthesia alone: a systematic review and meta-analysis. BMC Anesthesiol. 2021 Feb 15;21(1):52. doi: 10.1186/s12871-021-01273-1.
- Background Song T, Wu LJ, Li L. Comparison of combined intravenous and inhalation anesthesia and total intravenous anesthesia in laparoscopic surgery and the identification of predictive factors influencing the delayed recovery of neurocognitive function. Front Med (Lausanne). 2024 Mar 25;11:1353502. doi: 10.3389/fmed.2024.1353502. eCollection 2024.
- Background Wang Y, Cao M, Cao G, Liu Y, Zhang Y. Effect of combined intravenous-inhalation anesthesia on postoperative cognitive dysfunction after laparoscopic radical resection of cervical cancer: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020 Nov 6;99(45):e23124. doi: 10.1097/MD.0000000000023124.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Desflurane | Other / unclassified | 0.5 unknown | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 0.5 unknown | Inhaled |
| Background | Propofol | Small molecule | 2 ug/ml | Intravenous |
| Background | Propofol | Small molecule | 4 ug/ml | Intravenous |
| Background | Remifentanil | Small molecule | 1 ng/ml | Intravenous |
| Background | Remifentanil | Small molecule | 4 ng/ml | Intravenous |
Indications
No indication recorded.