drugset / Trial / NCT06330038
Anesthesia and Non-small Cell Lung Cancer Recurrence
Phase 4
Recruiting
5384 enrolled
Samsung Medical Center
All India Institute of Medical Sciences · collabAsan Medical Center · collabBeijing Hospital · collabChungnam National University Hospital · collabDongGuk University · collabEwha Womans University · collabInha University Hospital · collabKhon Kaen University · collabKing Chulalongkorn Memorial Hospital · collabKonkuk University Medical Center · collabKorea University Guro Hospital · collabMayo Clinic · collabMemorial Sloan Kettering Cancer Center · collabSeoul National University Hospital · collabSeoul St. Mary's Hospital · collabSeverance Hospital · collabThe Affiliated Hospital of Qingdao University · collabUniversity Hospitals Coventry and Warwickshire NHS Trust · collabUniversity of Texas Southwestern Medical Center · collabUniversity of Virginia · collabYale University · collab
RandomizedParallel-groupTriple-blindPrevention
Summary
There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of NSCLC is higher in patient who received total intravenous anesthesia (TIVA) than volatile anesthetics in this multi-center randomized trials.
Timeline
- Start
- 2024-08-05
- Primary completion
- 2028-12-31
- Completion
- 2028-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Desflurane | Other / unclassified | — | Inhaled |
| Comparator | Isoflurane | Other / unclassified | — | Inhaled |
| Subject | Propofol | Small molecule | — | Intravenous |
| Comparator | Sevoflurane | Other / unclassified | — | Inhaled |