Anesthetics in Rhytidoplasty - A Comparison Study

Completed 30 enrolled Mercy Facial Plastic Surgery Center

RandomizedParallel-groupTriple-blind

Summary

This study is a prospective, double-blind, randomized comparison study of different anesthesia methods in rhytidoplasty surgery. The study is designed to determine whether post-operative side-effect profiles in patients undergoing elective cosmetic facelift surgery can be decreased through the use of propofol/ketamine anesthesia with bispectral monitoring (PKA-BIS) rather than general anesthesia, without increasing intra-operative time, side-effect profiles, or patient recall. Approximately 30 subjects undergoing facelift surgery performed by the principal investigator will participate.

Timeline

Start: 2013-09
Primary completion: 2014-06
Completion: 2014-06

Publications

Jones KA, LaFerriere KA. Intravenous Anesthesia With Bispectral Index Monitoring vs Inhalational Anesthesia for Rhytidoplasty: A Randomized Clinical Trial. JAMA Facial Plast Surg. 2015 Jul-Aug;17(4):239-44. doi: 10.1001/jamafacial.2015.0222.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Desflurane	Other / unclassified	—	Inhaled
Subject	Ketamine	Small molecule	50 mg	Intravenous
Subject	Ketamine	Small molecule	200 mg	Intravenous
Subject	Propofol	Small molecule	—	Intravenous
Subject	Sevoflurane	Other / unclassified	—	Inhaled
Background	Bupivacaine	Other / unclassified	—	—
Background	Clonidine	Other / unclassified	0.1 mg	—
Background	Clonidine	Other / unclassified	0.2 mg	—
Background	Famotidine	Other / unclassified	20 mg	—
Background	Glycopyrrolate	Small molecule	0.2 mg	—
Background	Lidocaine	Other / unclassified	—	—
Background	Metoclopramide	Small molecule	10 mg	—
Background	Midazolam	Small molecule	2 mg	—
Background	Scopolamine	Unknown	1.5 mg	Other

Indications

No indication recorded.