Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy

Recruiting 138 enrolled Konya City Hospital

RandomizedParallel-groupSingle-blindPrevention

Summary

This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).

Timeline

Start: 2026-03-09
Primary completion: 2026-07-30
Completion: 2026-08-30

Publications

Background Jo YY, Chang YJ, Lee D, Kim YB, Jung J, Kwak HJ. Comparisons of Mechanical Power and Respiratory Mechanics in Pressure-Controlled Ventilation and Volume-Controlled Ventilation during Laparoscopic Cholecystectomy in Elderly Patients. J Pers Med. 2023 Jan 23;13(2):201. doi: 10.3390/jpm13020201.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Desflurane	Other / unclassified	6 %	—
Subject	Sevoflurane	Other / unclassified	2 %	Inhaled

Indications

No indication recorded.