LINC01844 as a Diagnostic Biomarker for POCD in Elderly Patients

Summary

Postoperative cognitive dysfunction (POCD) is a common complication after surgery that is associated with more adverse events and death. The goal of this randomized, controlled clinical study is to learn about the impact of different inhalation anesthetics may have on the elderly in terms of POCD and diagnosis performance of long intergenic non-coding RNA(LINC01844) level in blood of older people for POCD. The main question it aims to answer is: Dose the desflurane have less influence on the elderly's cognitive function in comparison with isoflurane？Does the relative level of LINC01844 in blood help diagnose POCD of older people after surgery? Participants undergoing elective lumbar decompression and fusion will finish neuropsychological evaluations one day before and 1st, 3rd and 5th day after surgery. At the same timepoint, the relative level of LINC01844 in blood will also be tested.

Timeline

Start

2024-04-23

Primary completion

2025-05-31

Completion

2025-05-31

Publications

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• Background Zhao Y, Ai Y. Overexpression of lncRNA Gm15621 alleviates apoptosis and inflammation response resulting from sevoflurane treatment through inhibiting miR-133a/Sox4. J Cell Physiol. 2020 Feb;235(2):957-965. doi: 10.1002/jcp.29011. Epub 2019 Jul 2.
• Background Niu X, Pu S, Ling C, Xu J, Wang J, Sun S, Yao Y, Zhang Z. lncRNA Oip5-as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR-29a to activate the SIRT1/AMPK/PGC1alpha pathway. Cell Prolif. 2020 Jun;53(6):e12818. doi: 10.1111/cpr.12818. Epub 2020 May 28.
• Background Tu Y, Zhu M, Wang Z, Wang K, Chen L, Liu W, Shi Q, Zhao Q, Sun Y, Wang X, Song E, Liu X. Melatonin inhibits Muller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. J Cell Physiol. 2020 Nov;235(11):8724-8735. doi: 10.1002/jcp.29716. Epub 2020 Apr 23.
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• Background Sun LY, Li XJ, Sun YM, Huang W, Fang K, Han C, Chen ZH, Luo XQ, Chen YQ, Wang WT. LncRNA ANRIL regulates AML development through modulating the glucose metabolism pathway of AdipoR1/AMPK/SIRT1. Mol Cancer. 2018 Aug 22;17(1):127. doi: 10.1186/s12943-018-0879-9.
• Jin D, Ma Y, Ji Y, Ge S. Impact of desflurane versus isoflurane on early cognitive function of the elderly undergoing lumbar surgery: a randomized clinical trial. BMC Anesthesiol. 2025 Dec 9;25(1):605. doi: 10.1186/s12871-025-03493-1.

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