Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine

Phase 4 Completed 90 enrolled University of California, San Diego

RandomizedParallel-groupDouble-blindOther

Summary

This study assesses the efficacy of sugammadex against neostigmine for hastening recovery from neuromuscular blockade and optimizing pulmonary function in obese patients with obstructive sleep apnea presenting for outpatient surgery. Both drugs are used in anesthesiology to reverse neuromuscular blockade that is given in the setting of inducing and maintaining general anesthesia.

Timeline

Start: 2021-01-04
Primary completion: 2023-01-04
Completion: 2024-01-04

Publications

Gabriel RA, Curran BP, Said ET, Tsuda PS, Bongbong DN, Deconde AS, Yan CH, Ingrande J. Neostigmine versus sugammadex on outpatient recovery among obese patients with obstructive sleep apnea: A randomized controlled trial. Sci Rep. 2026 Mar 31;16(1):15567. doi: 10.1038/s41598-026-47043-2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Neostigmine	Other / unclassified	—	—
Comparator	Sugammadex	Other / unclassified	—	—

Indications

No indication recorded.