Effect of Rocuronium and Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children
Summary
Sugammadex is the first selective relaxant binding agent approved to reverse certain non-depolarizing neuromuscular drugs in patients 2 years old and above. Although it has been in use over the last 10 years, more pharmacological studies are needed to understand its overall effects on participants. As investigators' primary outcome, the investigators aimed to investigate how differently sugammadex reverses neumuscular blockade caused by rocuronium under general anesthesia maintenance with sevoflurane compared with desflurane. Also, to compare the changes in peak airway pressure. As investigators' secondary outcome, the investigators aimed to compare the changes in heart rate and blood pressures after sugammadex injection under sevoflurane and desflurane general anesthesia.
Timeline
- Start
- 2018-12-28
- Primary completion
- 2019-05-19
- Completion
- 2019-05-19
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Sugammadex | Other / unclassified | 2 mg/kg | Intravenous |
| Comparator | Rocuronium | Other / unclassified | 0.6 mg/kg | Intravenous |
Indications
No indication recorded.