drugset / Trial / NCT02243943

Effect of Neuromuscular Reversal With Sugammadex on Postoperative Recovery Profile

NCT02243943

Phase 4 Completed 100 enrolled Leiden University Medical Center
RandomizedParallel-groupDouble-blindTreatment

Summary

Suboptimal reversal of neuromuscular blockage after surgery is possibly related to unfavorable postoperative respiratory conditions and elevated pain levels. Rapid and complete reversal of neuromuscular block was not possible untill sugammadex was discovered. The investigators hyposthesise that reversal with sugammadex leads to favorable postoperative respiratory conditions and less pain compared to reversal with neostigmine.

Timeline

Start
2014-09
Primary completion
2016-04
Completion
2016-04

Drugs

EvaluationDrugModalityDoseRoute
Comparator Neostigmine Other / unclassified 1 mg
Comparator Neostigmine Other / unclassified 2.5 mg
Subject Sugammadex Other / unclassified 2 mg/kg
Subject Sugammadex Other / unclassified 4 mg/kg

Indications