A New Approach of Neostigmine in Unavoidable Post Operative Ileus

Summary

Postoperative ileus (POI) in the absence of any mechanical obstruction remains a commonly encountered clinical problem.So, this study aimed to show the effective way to decrease the rate of postoperative Ileus (POI).

Timeline

Start

2007-08

Primary completion

2007-12

Completion

2008-02

Outcome

Met primary endpoint

paper Ten of the 11 patients who received neostigmine had prompt colonic decompression, as compared with none of the 10 patients who received placebo (P<0.001). PMID 10403850 ↗

Publications

• Results Ponec RJ, Saunders MD, Kimmey MB. Neostigmine for the treatment of acute colonic pseudo-obstruction. N Engl J Med. 1999 Jul 15;341(3):137-41. doi: 10.1056/NEJM199907153410301.

Drugs

Indications