drugset / Trial / NCT02703896
Prophylaxis for Aspiration of Gastric Contents.
RandomizedParallel-groupTriple-blindPrevention
Summary
Effect of orally administered two equal and consecutive doses of proton pump inhibitors, omeprazole, lansoprazole, esomeprazole , rabeprazole and pantoprazole and Histamine 2 receptor antagonists cimetidine, ranitidine,famotidine,nizatidine and lafutidine without and with a prokinetic agents domperidone, metoclopramide and erythromycin on intragastric pH, volume and bile refluxate.
Timeline
- Start
- 2012-01
- Primary completion
- 2012-01
- Completion
- 2015-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cimetidine | Small molecule | 200 mg | Oral |
| Subject | Drug either PPIS or H2RA and prokinetics | Unknown | 10 mg | Oral |
| Subject | Esomeprazole | Small molecule | 20 mg | Oral |
| Subject | Famotidine | Other / unclassified | 20 mg | Oral |
| Subject | Lafutidine | Small molecule | 10 mg | Oral |
| Subject | Lansoprazole | Other / unclassified | 15 mg | Oral |
| Subject | Metoclopramide | Small molecule | 10 mg | Oral |
| Subject | Nizatidine | Small molecule | 150 mg | Oral |
| Subject | Omeprazole | Other / unclassified | 20 mg | Oral |
| Subject | Pantoprazole | Other / unclassified | 20 mg | Oral |
| Subject | Rabeprazole | Small molecule | 10 mg | Oral |
| Subject | Ranitidine | Unknown | 150 mg | Oral |