drugset / Trial / NCT02939235

Influence of Metoclopramide on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine

NCT02939235

Phase 4 Completed 32 enrolled Collegium Medicum w Bydgoszczy
RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate differences in the pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite between patients who received ticagrelor and morphine followed by metoclopramide versus patients treated with ticagrelor and morphine alone for unstable angina pectoris.

Timeline

Start
2016-07
Primary completion
2017-12
Completion
2017-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Metoclopramide Small molecule 10 mg Intravenous
Comparator Ticagrelor Small molecule 180 mg Oral
Comparator Morphine Other / unclassified 5 mg Intravenous