Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED

Terminated 171 enrolled Vanderbilt University

RandomizedSingle-groupQuadruple-blindTreatment

Summary

The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population. We hypothesize that a single intravenous dose of ondansetron is more effective in reducing nausea than a single IV dose of metoclopramide, promethazine or normal saline placebo in undifferentiated adult emergency department patients.

Timeline

Start: 2007-03
Primary completion: 2008-10
Completion: 2008-10

Outcome

Outcome not reported

Stopped: “Conditional analysis showed observed differences were significantly less than power calculations”

Publications

Results Barrett TW, DiPersio DM, Jenkins CA, Jack M, McCoin NS, Storrow AB, Singleton LM, Lee P, Zhou C, Slovis CM. A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. Am J Emerg Med. 2011 Mar;29(3):247-55. doi: 10.1016/j.ajem.2009.09.028. Epub 2010 Mar 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Metoclopramide	Small molecule	10 mg	Intravenous
Comparator	Ondansetron	Other / unclassified	4 mg	Intravenous
Comparator	Promethazine	Small molecule	12.5 mg	Intravenous

Indications

No indication recorded.