Ondansetron Versus Metoclopramide in Treatment of Vomiting in Gastroenteritis

Phase 4 Completed 170 enrolled Hamad Medical Corporation

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Is intravenous metoclopramid as effective as intravenous ondansetron in the treatment of persistent vomiting in patients with acute gastroenteritis.

Timeline

Start: 2008-06
Primary completion: 2008-12
Completion: 2008-12

Outcome

Missed primary endpoint

paper Cessation of vomiting was achieved in 68/84 patients (81%) of the ondansetron and 60/83 (72%) of the metoclopramide groups, P = 0.14. PMID 21788756 ↗

Publications

Al-Ansari K, Alomary S, Abdulateef H, Alshawagfa M, Kamal K. Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis. J Pediatr Gastroenterol Nutr. 2011 Aug;53(2):156-60. doi: 10.1097/MPG.0b013e3182132d8d.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Metoclopramide	Small molecule	0.3 mg/kg	Intravenous
Subject	Ondansetron	Other / unclassified	0.15 mg/kg	Intravenous