drugset / Trial / NCT03081416

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

NCT03081416

Phase 3 Completed 80 enrolled Brooke Army Medical Center
RandomizedParallel-groupSingle-blindTreatment

Summary

This is a randomized, single-blind, placebo controlled trial to evaluate the efficacy of sub-dissociative dose ketamine versus standard care therapy for acute headache management of in patients presenting to the emergency department with headache as the chief compliant.

Timeline

Start
2016-05
Primary completion
2016-09
Completion
2017-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Ketamine Small molecule 0.75 mg/kg Intranasal
Comparator Dexamethasone Small molecule 10 mg
Comparator Diphenhydramine Unknown 25 mg Intravenous
Comparator Ketorolac Other / unclassified 15 mg Intravenous
Comparator Ketorolac Other / unclassified 30 mg Intravenous
Comparator Metoclopramide Small molecule 10 mg Intravenous

Indications