drugset / Trial / NCT03081416
"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
RandomizedParallel-groupSingle-blindTreatment
Summary
This is a randomized, single-blind, placebo controlled trial to evaluate the efficacy of sub-dissociative dose ketamine versus standard care therapy for acute headache management of in patients presenting to the emergency department with headache as the chief compliant.
Timeline
- Start
- 2016-05
- Primary completion
- 2016-09
- Completion
- 2017-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketamine | Small molecule | 0.75 mg/kg | Intranasal |
| Comparator | Dexamethasone | Small molecule | 10 mg | — |
| Comparator | Diphenhydramine | Unknown | 25 mg | Intravenous |
| Comparator | Ketorolac | Other / unclassified | 15 mg | Intravenous |
| Comparator | Ketorolac | Other / unclassified | 30 mg | Intravenous |
| Comparator | Metoclopramide | Small molecule | 10 mg | Intravenous |