drugset / Trial / NCT02972502

Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department

NCT02972502

Phase 4 Terminated 66 enrolled OhioHealth
RandomizedParallel-groupSingle-blindTreatment

Summary

Metoclopramide (Reglan) is a common agent used for relief of headaches in the emergency department (ED).In this study the investigators seek to explore another option for treatment of headaches in the ED, one that may be more efficacious and efficient. Haloperidol (Haldol), a butyrophenone class of medication, is thought to act by affecting the dopamine 2 receptor in the brain. By exploring haloperidol as an option for treatment, the investigators hope to discover a more efficient and effective medication for the treatment of non-traumatic headaches, thereby decreasing a patient's length of stay in the department and decreasing the rate of return visits for continued discomfort from the same headache. This study could lead to the increased usage of haloperidol as a first line agent in the treatment of prolonged headaches presenting to the ED.

Timeline

Start
2014-02
Primary completion
2017-04-24
Completion
2017-04-24

Drugs

EvaluationDrugModalityDoseRoute
Subject Haloperidol Other / unclassified 2.5 mg Intravenous
Comparator Metoclopramide Small molecule 10 mg Intravenous
Background Diphenhydramine Unknown 25 mg Intravenous

Indications