drugset / Trial / NCT01191645
Opioid Effects on Swallowing and Esophageal Sphincter Pressure
RandomizedCrossoverTriple-blindTreatment
Summary
The purpose of this study is to determine whether a dopamine receptor antagonist metoclopramide can counteract opioid induced effects on esophageal motility and lower esophageal sphincter. The aim of this study is also to evaluate if the opioid antagonist naloxone reduces the opioid induced pharyngeal and esophageal dysfunction.
Timeline
- Start
- 2010-10
- Primary completion
- 2010-11
- Completion
- 2010-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metoclopramide | Small molecule | 0.2 mg/kg | Intravenous |
| Comparator | Naloxone | Small molecule | 0.1 ug/kg | — |
| Subject | Remifentanil | Small molecule | 3 ng/ml | — |