drugset / Trial / NCT02288923

Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement.

NCT02288923

RandomizedParallel-groupSingle-blindTreatment

Summary

Pain after a knee replacement can impair recovery and use of the new knee. Having an injection to numb the femoral nerve is known to give good pain relief after the operation but may lead to slower mobilisation as it also prevents the patient from moving the knee. Recent studies have shown that infiltration of local anaesthetic (LIA) within the new knee joint may also give good pain relief. The null hypothesis is that there is no difference in primary or secondary outcome measures between femoral nerve block and LIA, as anaesthetic techniques for knee replacement.

Timeline

Start
2015-03
Primary completion
2018-07-01
Completion
2018-07-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 1 g Intravenous
Comparator Cyclizine Small molecule 50 mg
Comparator Dexamethasone Small molecule 4 mg Intravenous
Comparator Diazepam Small molecule 2 mg Oral
Comparator Diazepam Small molecule 5 mg Oral
Comparator Gentamicin Small molecule 3 mg/kg Intravenous
Comparator Ibuprofen Small molecule 400 mg
Comparator Metoclopramide Small molecule
Comparator Morphine Other / unclassified 10 mg Oral
Comparator Morphine Other / unclassified 20 mg Oral
Comparator Morphine Other / unclassified 30 mg Oral
Comparator Ondansetron Other / unclassified 4 mg Intravenous
Comparator Ranitidine Unknown
Comparator Teicoplanin Other / unclassified 6 mg/kg Intravenous
Comparator Temazepam Small molecule 10 mg Oral
Comparator Temazepam Small molecule 20 mg Oral
Comparator Tranexamic Acid Small molecule 500 mg Intravenous
Comparator Tranexamic Acid Small molecule 1 g Intravenous

Indications