Drugs / Gentamicin
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Gentamicin

Small molecule targets CFTR via restoration

Developed for
cutaneous leishmaniasis · urinary tract infection · infectious disease · ulcer of lower limbs · appendicitis · acoustic neuroma · bacterial infectious disease · gonorrhea
+64 more · infectious disease with sepsis · recessive dystrophic epidermolysis bullosa · abscess · atopic eczema · chronic rhinosinusitis · Duchenne muscular dystrophy · infective endocarditis · junctional epidermolysis bullosa Herlitz type · peritonitis · pneumonia · respiratory tract infectious disorder · sinusitis · skin infection · acute cholangitis · acute intestinal ischemia · alcoholic hepatitis · bacterial infectious disease with sepsis · bacterial meningitis · bacterial pneumonia · Becker muscular dystrophy · benign prostatic hyperplasia · breast disorder · bronchiectasis · bubonic plague · cat-scratch disease · cholangitis · chronic ulcer of skin · colon carcinoma · Crohn's colitis · cystic fibrosis · endophthalmitis · epidermolysis bullosa · esophagitis · ichthyosis · infectious peritonitis · interstitial cystitis · Klebsiella pneumonia · periapical periodontitis · plague · pneumonic plague · prosthesis-related infectious disease · rectal cancer · staphylococcus aureus infection · stomatitis · tracheobronchitis · ulcerative colitis · vestibular disorder · bacterial urinary tract infection · bullous pemphigoid · chorioamnionitis · cystitis · dermatitis · endometritis · HIV infectious disease · hypotrichosis simplex · infectious meningitis · keratitis · Klebsiella infectious disease · Meniere disease · neonatal sepsis · pemphigus vulgaris · periprosthetic joint infection · preterm premature rupture of the membranes · protein-energy malnutrition
Investigated by
U.S. Army Medical Research and Development Command · Innocoll · Assistance Publique - Hôpitaux de Paris · Premier Research · University of Southern California · Hospital General Universitario Elche
+129 more · Academic Medical Center - University of Amsterdam · University of Florida · Walter Reed Army Institute of Research (WRAIR) · ZonMw: The Netherlands Organisation for Health Research and Development · Assiut University · Duke University · HaEmek Medical Center, Israel · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Lund University · Muhimbili Orthopaedic Institute · National Institute of Allergy and Infectious Diseases (NIAID) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · National Institute of Neurological Disorders and Stroke (NINDS) · Phramongkutklao College of Medicine and Hospital · Silpakorn University · Stony Brook University · University Hospital, Toulouse · University of California, San Francisco · University of Copenhagen · University of Oxford · Aalborg University Hospital · Aarhus University Hospital · Aga Khan University · Al-Rasheed University College · Alice Ho Miu Ling Nethersole Hospital · Amsterdam UMC, location VUmc · Balgrist University Hospital · Baylor College of Medicine · Centers for Disease Control and Prevention · Chulalongkorn University · Combined Military Hospital Quetta · Dallas VA Medical Center · Department for International Development, United Kingdom · Department of Health and Human Services · Esbjerg Hospital - University Hospital of Southern Denmark · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Flevoziekenhuis · Food and Drug Administration (FDA) · Foreign, Commonwealth and Development Office and Wellcome (216273.Z.19.Z) · Gillette Children's Specialty Healthcare · Henry Ford Health System · Herlev and Gentofte Hospital · Hitit University · Hoth Therapeutics, Inc. · Hôpital Universitaire Joseph Raseta Befelatanana CHU d'Antananarivo · Indiana University · Institut Pasteur · Institut Pasteur de Madagascar · Istanbul Medipol University Hospital · Johns Hopkins Bloomberg School of Public Health · Julie Wei, MD · Kamuzu University of Health Sciences · Kenya Ministry of Health · Kwong Wah Hospital · Lahey Clinic · Lahore General Hospital · London School of Hygiene and Tropical Medicine · MEDSI Clinical Hospital 1, ICU · Mansoura University · Medical Research Council · Medical University of Vienna · Medstar Health Research Institute · Memorial Sloan Kettering Cancer Center · Merck & Co., Inc. · Michael E. DeBakey VA Medical Center · Mikkel Herly · Ministry of Health, Madagascar · Ministry of Health, Uganda · Murdoch Childrens Research Institute · National Institute for Health Research, United Kingdom · National Institutes of Health (NIH) · National University of Malaysia · Nationwide Children's Hospital · Nektar Therapeutics · all 135 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) GARAMYCIN — 1966-03-15 fda.gov ↗

Trials 120 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT07643974 Jun 2026 → Sep 2027 expected multiple sclerosis, spina bifida, spinal cord injury, urinary bladder disorder +1 Medstar Health Research Institute Not yet recruiting No outcome recorded
Phase 0 NCT01633762 Apr 2012 → Apr 2013 diabetes mellitus, obesity disorder, osteoporosis University Hospital, Gentofte, Copenhagen Completed No outcome recorded
Phase 0 NCT01878643 Dec 2001 → Dec 2002 primary bacterial infectious disease, respiratory failure, respiratory tract infectious disorder Stony Brook University Completed No outcome recorded
Phase 15 trials
Phase 1 NCT04544943 May 2021 → Sep 2022 atopic eczema Hoth Therapeutics, Inc. Completed No outcome recorded
Phase 1 NCT04967859 Jul 2018 → Nov 2019 — São Paulo State University Completed No outcome recorded
Phase 1 NCT02515448 Oct 2015 → Nov 2016 — Poitiers University Hospital Completed No outcome recorded
Phase 1 NCT00451074 Mar 2007 → Jul 2009 Duchenne muscular dystrophy Nationwide Children's Hospital Completed No outcome recorded
Phase 1 NCT00005574 Feb 2000 → Jan 2001 Becker muscular dystrophy, Duchenne muscular dystrophy National Institute of Neurological Disorders and Stroke (NINDS) Completed No outcome recorded
Phase 1/27 trials · 1 met primary
Phase 1/2 NCT04644627 Dec 2020 → Jan 2022 epidermolysis bullosa Oslo University Hospital Completed No outcome recorded
Phase 1/2 NCT04140786 Oct 2019 → Nov 2023 junctional epidermolysis bullosa Herlitz type University of Southern California Unknown No outcome recorded
Phase 1/2 NCT03392909 Jul 2018 → Dec 2023 recessive dystrophic epidermolysis bullosa University of Southern California Unknown No outcome recorded
Phase 1/2 NCT03526159 Jun 2018 → Jul 2020 overdue junctional epidermolysis bullosa Herlitz type University of Southern California Recruiting No outcome recorded
Phase 1/2 NCT03012191 Feb 2017 → May 2018 recessive dystrophic epidermolysis bullosa University of Southern California Completed No outcome recorded
Phase 1/2 NCT02698735 Feb 2016 → Mar 2017 recessive dystrophic epidermolysis bullosa University of Southern California Completed Met primary
Phase 1/2 NCT02036528 Jan → Dec 2014 ulcer of lower limbs Royer Biomedical, Inc. Terminated No outcome recorded
Phase 224 trials · 1 met primary
Phase 2 NCT06007352 Oct 2024 → Oct 2025 infectious disease with sepsis, urinary tract infection Yale University Withdrawn No outcome recorded Stop: Business
Phase 2 NCT06362447 Sep 2024 → Apr 2026 overdue ichthyosis University Hospital, Toulouse Not yet recruiting No outcome recorded
Phase 2 NCT07407491 Jul 2024 → Jul 2026 overdue acute cholangitis, biliary tract cancer, choledocholithiasis National University of Malaysia Recruiting No outcome recorded
Phase 2 NCT05303909 May 2022 → May 2024 — Singapore General Hospital Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT05287425 Aug 2019 → Aug 2023 — Medical University of Vienna Completed No outcome recorded
Phase 2 NCT04039750 Jul 2019 → Dec 2026 expected appendicitis Prisma Health-Upstate Active not recruiting No outcome recorded
Phase 2 NCT03476941 Apr 2019 → Oct 2020 abscess University of Iowa Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT03931408 Feb 2019 → Jul 2020 spinal cord injury University of Louisville Completed No outcome recorded
Phase 2 NCT03778008 Dec 2018 → Dec 2019 stomatitis Second Affiliated Hospital of Nanchang University Unknown No outcome recorded
Phase 2 NCT02784821 Jan 2017 → Sep 2019 bacterial infectious disease, bronchopulmonary dysplasia, intestinal perforation, intracerebral hemorrhage +3 University of Florida Completed No outcome recorded
Phase 2/34 trials · 1 met primary
Phase 2/3 NCT04238923 May 2020 → May 2021 peripheral vascular disease London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Unknown No outcome recorded
Phase 2/3 NCT03632109 Sep 2018 → Mar 2019 gonorrhea University of Washington Terminated No outcome recorded
Phase 2/3 NCT03503513 Aug 2018 → Sep 2023 spinal cord injury, urinary tract infection University of Michigan Completed Met primary
Phase 2/3 NCT00128466 Aug 2004 → Feb 2007 plague Centers for Disease Control and Prevention Completed No outcome recorded
Phase 324 trials · 3 met primary · 2 missed
Phase 3 NCT06841003 Feb 2025 → Jun 2027 expected abscess, appendicitis Spaarne Gasthuis Recruiting No outcome recorded
Phase 3 NCT06387147 Jan 2025 → Nov 2027 expected acute intestinal ischemia Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT05766670 Apr 2024 → Jan 2027 expected osteomyelitis Wake Forest University Health Sciences Recruiting No outcome recorded
Phase 3 NCT05502380 Sep 2022 → Dec 2024 overdue bacterial infectious disease Balgrist University Hospital Recruiting No outcome recorded
Phase 3 NCT04731025 Jan 2021 → Sep 2026 overdue breast disorder, poisoning, prosthesis-related infectious disease Mikkel Herly Active not recruiting No outcome recorded
Phase 3 NCT04110340 Feb 2020 → Apr 2024 bubonic plague, pneumonic plague University of Oxford Completed Met primary
Phase 3 NCT04041791 Aug 2019 → Apr 2024 pneumonia University of Oxford Completed No outcome recorded
Phase 3 NCT03491540 Sep 2018 → Oct 2023 rectal cancer Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT03475680 Aug 2018 → Aug 2021 colon carcinoma Assistance Publique - Hôpitaux de Paris Terminated No outcome recorded
Phase 3 NCT03303677 Apr → Nov 2018 chronic rhinosinusitis University of Florida Withdrawn No outcome recorded
Phase 432 trials · 2 met primary · 1 missed
Phase 4 NCT07563504 Jul 2026 → Jan 2027 expected — Sarawak General Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07220967 Oct 2025 → Oct 2027 expected breast cancer Memorial Sloan Kettering Cancer Center Recruiting No outcome recorded
Phase 4 NCT06332781 Apr → Sep 2025 urinary tract infection Women and Infants Hospital of Rhode Island Completed No outcome recorded
Phase 4 NCT06209047 Oct 2023 → May 2026 overdue bronchiectasis Assiut University Recruiting No outcome recorded
Phase 4 NCT06332040 Oct 2023 → Oct 2026 expected urinary tract infection St. Joseph's Hospital and Medical Center, Phoenix Recruiting No outcome recorded
Phase 4 NCT05862402 May 2023 → May 2024 Klebsiella pneumonia Phramongkutklao College of Medicine and Hospital Unknown No outcome recorded
Phase 4 NCT05157126 Sep 2022 → Apr 2028 expected — University of California, San Francisco Recruiting No outcome recorded
Phase 4 NCT04876131 May 2022 → Jan 2028 expected urinary tract infection Murdoch Childrens Research Institute Recruiting No outcome recorded
Phase 4 NCT04753723 Feb → Nov 2021 skin infection The Metis Foundation Completed No outcome recorded
Phase 4 NCT03483363 Oct 2018 → Jan 2022 — The University of Texas Health Science Center, Houston Terminated No outcome recorded Stop: Enrollment
Phase not applicable21 trials · 1 met primary
— NCT07655050 Jun 2026 → Feb 2027 expected nephrolithiasis, urinary tract infection Hitit University Recruiting No outcome recorded
— NCT07311395 Dec 2025 → Jan 2027 expected — Western Galilee Hospital-Nahariya Recruiting No outcome recorded
— NCT07478874 Jul → Dec 2025 — Lahore General Hospital Completed No outcome recorded
— NCT07704398 Oct 2023 → Apr 2026 periapical periodontitis Istanbul Medipol University Hospital Completed No outcome recorded
— NCT05750966 Jul 2023 → Apr 2026 cholangitis Academic Medical Center - University of Amsterdam Completed No outcome recorded
— NCT05251584 Dec 2021 → Mar 2023 infectious peritonitis Phramongkutklao College of Medicine and Hospital Unknown No outcome recorded
— NCT04839653 May 2021 → Apr 2022 acute respiratory distress syndrome, bacterial infectious disease, infectious disease with sepsis, pneumonia MEDSI Clinical Hospital 1, ICU Unknown No outcome recorded
— NCT05355610 Apr 2021 → Apr 2022 vestibular disorder Combined Military Hospital Quetta Unknown No outcome recorded
— NCT06454643 Jan 2020 → Jan 2021 — Al-Rasheed University College Completed Mixed
— NCT03559400 Nov 2019 → Sep 2021 — University of California, San Francisco Completed No outcome recorded
Comparator or background therapy66 trials
Phase 0 NCT02099240 Comparator Mar 2014 → Nov 2018 osteomyelitis University of Louisville Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT03213249 Comparator Jul 2017 → Sep 2018 breast disorder Washington University School of Medicine Completed No outcome recorded
Phase 2 NCT06428448 Background Feb 2026 → Aug 2027 expected periprosthetic joint infection OsteoRemedies, LLC Recruiting No outcome recorded
Phase 2 NCT05702762 Comparator Oct 2022 → Jun 2023 cystitis Mercy Health Ohio Unknown No outcome recorded
Phase 2 NCT04246996 Comparator Jan 2020 → Dec 2021 female stress incontinence, pelvic organ prolapse, urinary tract infection Kaiser Permanente Completed No outcome recorded

Evidence & citations 19 cited values

Every value below carries the sentence it was read from. 187 sources stand behind the page.

FieldValueCited text
Known as Gentamicin “Each subject will receive a single dose of 15 mg/kg vancomycin; 2 mg/kg gentamicin and 250 mg levofloxacin administered intravenously over a one-hour infusion period through...” NCT00596167 ↗
163

“Some commonly used antibiotics for the treatment of PD peritonitis with their suggested concentrations in the antibiotic-lock are quoted as below: Cefazolin 10mg/mL...” NCT05971537 ↗

“Assessment of Cutaneous Leishmaniasis Scar (Caused by Leishmania Major) for Cosmetic Outcome After Treatment With WR279396 (Paromomycin/Gentamicin Cream in Vehicle) Versus a No...” NCT00490230 ↗

“A sample of 802 ELBW preterm infants will undergo web-based stratified block randomization to receive empiric antibiotics (EA; ampicillin and gentamicin) or placebo during...” PMID 35606829 ↗ May 2022

“Antibiotics: Ceftazidime-Avibactam or Combination antibiotics (eg. Meropenem-Colistin, Imipenem-Colistin, Tigecycline-Amikacin, Tigecycline-Gentamicin, Tigecycline-Meropenem or...” NCT05862402 ↗

“Participants were randomly assigned into two groups: a standard root canal treatment group (n = 40) and an adjunctive treatment group receiving submucosal betamethasone and...” NCT07704398 ↗

“WR 279,396 is a topical antibiotic cream containing paromomycin and gentamicin that will be applied to each lesion once a day for 20 days and covered with a sterile gauze and...” NCT01494350 ↗

“OBJECTIVE: To evaluate the efficacy of intraocular gentamicin sulfate and clindamycin in the prevention of acute posttraumatic bacterial endophthalmitis following penetrating...” PMID 17420365 ↗ Apr 2007

“WR 279,396 is a topical antibiotic cream containing 15% paromomycin and 0.5% gentamicin that will be applied to each lesion once a day and covered with a steril” NCT00606580 ↗

“Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: a randomized controlled study.” PMID 12138146 ↗ Aug 2002

“ampicillin 50mg/kg twice daily and gentamicin \[3mg/kg for babies \<2kg or 5mg/kg for babies \>2kg\] once daily for 7 days, as per Kenyan guidelines).” NCT03453177 ↗

Show 153 more sources

Known as AppliGel-G “AppliGel-G is a topically applied hydrogel formulation of gentamicin sulfate (GMS).” NCT02036528 ↗
Known as Garamycin “Gentamicin, Garamycin” NCT04140786 ↗
2

NCT05594472 ↗

NCT01266499 ↗

Known as Garamycin Sponge “Garamycin Sponge (Gentamicin-Collagen sponge)” NCT01951768 ↗
Known as Gentamicin (gentamicin) “Gentamicin (gentamicin)” NCT00596167 ↗
Known as Gentamicin Sulfate “containing Type I bovine collagen and 50 mg of gentamicin sulfate (equivalent to 32.5 mg of gentamicin base)” NCT01951768 ↗
11

“AppliGel-G is a topically applied hydrogel formulation of gentamicin sulfate (GMS).” NCT02036528 ↗

“Gentamicin Sulfate Inj 20mg/2ml vial for injection” NCT03476941 ↗

“Gentamicin Sulfate, Topical” NCT05143164 ↗

“Drug: Gentamicin Sulfate” NCT03012191 ↗

NCT03503513 ↗

NCT04041791 ↗

NCT04246996 ↗

NCT00671528 ↗

NCT04644627 ↗

NCT03931408 ↗

Show 1 more source

Known as Gentamicin Sulphate “delivers a consistent dose of fast-release antibiotics called Gentamicin Sulphate (2.0 mg/cm2).” NCT01667874 ↗
Known as Gentamicin topical gel “The purpose of this study is to determine whether AppliGel-G (Gentamicin topical gel) plus oral Ciprofloxacin / Doxycycline are safe and effective in the treatment of mild to...” NCT02036528 ↗
Known as Gentamicin, Garamycin “Gentamicin, Garamycin” NCT03012191 ↗
Known as Gentamicin-Collagen sponge “The gentamicin-collagen sponge, a surgically implantable topical antibiotic, is currently approved in 54 countries.” PMID 20716738 ↗ Aug 2010
1

“Garamycin Sponge (Gentamicin-Collagen sponge)” NCT01951768 ↗

Known as Gentamicins “Drug: Gentamicins” NCT02379754 ↗
Known as gentamycin “The aim of this study is to investigate whether topical aminoglycosides (Gentamycin) may be beneficial for the treatment of HHS patients carrying nonsense mutations by inducing...” NCT03492866 ↗
16

“mLDG (lidocaine 0.16mg/mL, dexamethasone 0.02mg/mL, and gentamycin 0.16mg/mL) dissolved in 0.9% saline solution was administered three times a day.” NCT02577393 ↗

“Patients with known allergy to one of the drugs may be treated with oral Gentamycin (2.5mg/KgX3/d) for 3 weeks instead of the allergenic drug.” NCT02033408 ↗

“Clindamycin 2700mg+gentamycin 240mg+ 250ml sterile saline solution i.v. once a day until clinical improvement” NCT02309346 ↗

“an impirical antibiotic (gentamycin 80 mg).” NCT03007225 ↗

“Clindamycin 600 mg + Gentamycin 2 mg/kg.” NCT04438655 ↗

“Gentamycin-80mg in 60ml sterile water” NCT04285320 ↗

NCT04839653 ↗

NCT01945450 ↗

NCT03688659 ↗

NCT03157388 ↗

Show 6 more sources

Known as Gentamycin-Gentamicin “Gentamycin-Gentamicin®” NCT02033408 ↗
Known as GMS “AppliGel-G is a topically applied hydrogel formulation of gentamicin sulfate (GMS).” NCT02036528 ↗
Known as Hexamycin “gentamycin 40 mg ("Hexamycin®"), solution” NCT03157388 ↗
1

“gentamycin 40 mg ("Hexamycin®")” NCT01633762 ↗

Action Restore “gentamicin was shown to restore functional dystrophin in a mouse model of DMD.” NCT00005574 ↗
Modality Small molecule “aminoglycoside antibiotics (gentamicin)” NCT00484055 ↗
Route Intravenous “Gentamicin will be given intravenously (through a vein) once a day for 14 days.” NCT00005574 ↗
Target CFTR “Suppression of stop mutations in the CFTR gene with parenteral gentamicin” NCT00376428 ↗