Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition

Phase 2/3 Unknown 300 enrolled Makerere University

RandomizedParallel-groupOpen-labelTreatment

Summary

This study to investigate whether empiric use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard-of-care (ampicillin plus gentamicin) will reduce mortality among HIV-infected/HEU children admitted to Mwanamugimu Nutrition Unit, Mulago Hospital, Kampala, Uganda.

Timeline

Start: 2021-06-14
Primary completion: 2024-06-14
Completion: 2024-06-14

Publications

Musiime V, Kiggwe A, Beinomugisha J, Kakooza L, Thembo-Mwesige J, Nkinzi S, Naguti E, Atuhaire L, Segawa I, Ssengooba W, Mukonzo JK, Babirekere-Iriso E, Musoke P. Strategies to Reduce Mortality Among Children Living With HIV and Children Exposed to HIV but Are Uninfected, Admitted With Severe Acute Malnutrition at Mulago Hospital, Uganda (REDMOTHIV): A Mixed Methods Study. Front Pediatr. 2022 Jun 24;10:880355. doi: 10.3389/fped.2022.880355. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ampicillin	Unknown	50 mg/kg	Intravenous
Subject	Ceftriaxone	Other / unclassified	50 mg/kg	Intravenous
Subject	Ceftriaxone	Other / unclassified	75 mg/kg	Intravenous
Comparator	Gentamicin	Small molecule	5 mg/kg	Intravenous

Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition

Summary

Timeline

Publications

Drugs

Indications