Drugs / Ceftriaxone
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Ceftriaxone

Other / unclassified

Developed for
pneumonia · infectious disease with sepsis · acute pyelonephritis · appendicitis · bacterial infectious disease · gonorrhea · HIV infectious disease · protein-energy malnutrition
+60 more · cirrhosis of liver · infective endocarditis · puerperal infection · urinary tract infection · articular cartilage disorder · aspiration pneumonia · aspiration pneumonitis · bacterial infectious disease with sepsis · bacterial meningitis · bacterial pneumonia · bacterial urinary tract infection · bacterial vaginosis · bipolar disorder · cellulitis · cervical incompetence · cholangitis · COVID-19 · critical illness polyneuropathy · diarrheal disease · endocarditis · escherichia coli infection · esophageal varices with bleeding · hidradenitis suppurativa · infectious disease · infectious disorder of the nervous system · infectious peritonitis · intestinal infectious disease · liver disorder · Lyme disease · meningitis · mouth mucosa disorder · neurosyphilis · Parkinson disease · post-treatment Lyme disease syndrome · preterm premature rupture of the membranes · pulmonary non-tuberculous mycobacterial infection · respiratory tract infectious disorder · salmonellosis · schizoaffective disorder · schizophrenia · streptococcal pneumonia · typhoid fever · ulcerative colitis · abscess · amyotrophic lateral sclerosis · bacterial arthritis · bipolar depression · cholecystitis · diverticulitis · endometritis · gram-negative bacterial infections · infective arthritis · liver abscess (disease) · nosocomial infection · osteomyelitis · peritonitis · pyelonephritis · shigellosis · staphylococcal infection · syphilis
Investigated by
Andalusian Public Foundation for Health Research in Seville · University of Oxford · Makerere University · Merck Sharp & Dohme LLC · Assistance Publique Hopitaux De Marseille · Hoffmann-La Roche
+138 more · KEMRI-Wellcome Trust Collaborative Research Program · London School of Hygiene and Tropical Medicine · Ministry of Health, France · National Institute of Allergy and Infectious Diseases (NIAID) · Pfizer · Spanish Network for Research in Infectious Diseases · Theriva Biologics, Inc. · University College, London · Xiangbei Welman Pharmaceutical Co., Ltd · Academic Medical Center - University of Amsterdam · Aga Khan University · Ahmad Zia · Ain Shams Maternity Hospital · Albert Schweitzer Hospital · American Association for the Study of Liver Diseases · Amsterdam UMC, location VUmc · Assistance Publique - Hôpitaux de Paris · Assiut University · Association Pour La Promotion A Tours De La Reanimation Medicale · Austin V Stone · Australian and New Zealand Intensive Care Research Centre · Baxter Healthcare Corporation · Berry Consultants · Beth Israel Deaconess Medical Center · Biopharma (Orofino Pharmaceuticals Group) · BrainX Corporation · CH SOISSONS · Centre Hospitalier Roubaix · Centre Hospitalier Universitaire de Besancon · Centre Hospitalier Universitaire de Caen · Centre Hospitalier Universitaire de Nice · Centre Hospitalier Universitaire, Amiens · Centre Hospitalier de Beauvais · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal · Centre for Clinical Research, Kenya Medical Research Institute · Centre for Microbiology Research, Kenya Medical Research Institute · Centre for Research in Therapeutic Sciences, Strathmore University, Nairobi Kenya · Chang Gung Memorial Hospital · Columbia Clinical Trials Network for Lyme and Other Tick-Borne Diseases · David J. Gagnon · Department for International Development, United Kingdom · E-DA Hospital · Erasmus Medical Center · Far Eastern Memorial Hospital · Fondo de Investigacion Sanitaria · French Society for Intensive Care · GlaxoSmithKline · Global Coalition for Adaptive Research · HaEmek Medical Center, Israel · Hackensack Meridian Health · Haiphong University of Medicine and Pharmacy · Halozyme Therapeutics · Hospital Mutua de Terrassa · Hospital Universitario Principe de Asturias · Hôpital Les Bateliers, CHU de Lille · IL Sogno di Stefano · Imperial College London · Innoviva Specialty Therapeutics · Institut Pasteur · Intensive Care National Audit & Research Centre · Johns Hopkins All Children's Hospital · Kamuzu University of Health Sciences · Kenya Medical Research Institute · Kenya Ministry of Health · Korea University · MEDSI Clinical Hospital 1, ICU · Maasstad Hospital · MaineHealth · Manimarane Arjunan, MD,DM (Cardiology) · Massachusetts General Hospital · Mbarara University of Science and Technology · Medical College of Wisconsin · Medical Research Council · Medical Research Institute of New Zealand · all 144 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) ROCEPHIN KIT — 1984-12-21 fda.gov ↗

Trials 86 · started per year

today
US approved 1984
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04977882 Oct 2020 → Aug 2022 colon carcinoma University of Rome Tor Vergata Completed No outcome recorded
Phase 13 trials · 1 met primary
Phase 1 NCT03895567 Dec 2026 — University of Oxford Suspended No outcome recorded Stop: Business
Phase 1 NCT05724628 Oct → Nov 2023 appendicitis University of Texas Southwestern Medical Center Withdrawn No outcome recorded
Phase 1 NCT00493220 Jun → Sep 2007 — Baxter Healthcare Corporation Completed Met primary
Phase 1/24 trials
Phase 1/2 NCT06785402 May 2026 post-treatment Lyme disease syndrome Hackensack Meridian Health Withdrawn No outcome recorded Stop: Enrollment
Phase 1/2 NCT02473640 Jun 2015 → Apr 2016 — Theriva Biologics, Inc. Completed No outcome recorded
Phase 1/2 NCT02419001 Mar → Sep 2015 — Theriva Biologics, Inc. Completed No outcome recorded
Phase 1/2 NCT00591318 Oct 2007 → Mar 2011 schizoaffective disorder, schizophrenia Research Foundation for Mental Hygiene, Inc. Terminated No outcome recorded Stop: Enrollment
Phase 214 trials · 1 met primary · 2 missed
Phase 2 NCT07485010 Apr 2027 → Apr 2031 expected pulmonary non-tuberculous mycobacterial infection The University of Queensland Not yet recruiting No outcome recorded
Phase 2 NCT06406114 May 2025 → Jul 2028 expected anaphylaxis, drug allergy, drug pseudoallergy Massachusetts General Hospital Recruiting No outcome recorded
Phase 2 NCT05470517 Jan 2023 → Feb 2024 appendicitis Johns Hopkins All Children's Hospital Completed No outcome recorded
Phase 2 NCT05375240 Jun 2022 → Jun 2024 ischemic stroke Tianjin Medical University General Hospital Unknown No outcome recorded
Phase 2 NCT05149287 Dec 2021 → Apr 2022 articular cartilage disorder Austin V Stone Terminated No outcome recorded Stop: Business
Phase 2 NCT04999592 Aug 2021 → Mar 2024 cardiac arrest, pneumonia David J. Gagnon Terminated Missed primary Stop: Business
Phase 2 NCT05216744 Jul 2021 → Feb 2022 chlamydia trachomatis infectious disease, gonorrhea Haiphong University of Medicine and Pharmacy Completed Met primary
Phase 2 NCT03794765 Apr 2019 → Mar 2020 ulcerative colitis Post Graduate Institute of Medical Education and Research, Chandigarh Completed Missed primary
Phase 2 NCT03413384 Feb 2019 → Jul 2025 overdue Parkinson disease BrainX Corporation Active not recruiting No outcome recorded
Phase 2 NCT03681431 Apr 2018 → Apr 2019 infective endocarditis Andalusian Public Foundation for Health Research in Seville Completed No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT06527989 Sep 2024 → Sep 2025 overdue — Assiut University Not yet recruiting No outcome recorded
Phase 2/3 NCT05051163 Jun 2021 → Jun 2024 HIV infectious disease, protein-energy malnutrition Makerere University Unknown No outcome recorded
Phase 2/3 NCT02561442 Oct → Dec 2015 — scPharmaceuticals, Inc. Completed No outcome recorded
Phase 318 trials · 3 met primary · 1 missed
Phase 3 NCT06572761 Sep 2026 → May 2030 expected cervical incompetence Assistance Publique - Hôpitaux de Paris Not yet recruiting No outcome recorded
Phase 3 NCT07710118 Jul 2026 → Dec 2028 expected gonorrhea National Taiwan University Hospital Recruiting No outcome recorded
Phase 3 NCT05821478 May 2025 → Feb 2027 expected hidradenitis suppurativa Institut Pasteur Recruiting No outcome recorded
Phase 3 NCT05654896 Nov 2022 → Nov 2023 — Nadeem Iqbal Unknown No outcome recorded
Phase 3 NCT04041791 Aug 2019 → Apr 2024 pneumonia University of Oxford Completed No outcome recorded
Phase 3 NCT03174236 Sep 2017 → Jan 2020 poisoning, protein-energy malnutrition University of Oxford Unknown No outcome recorded
Phase 3 NCT02389036 May 2017 → Apr 2023 critical illness polyneuropathy, infectious disease with sepsis The George Institute Completed No outcome recorded
Phase 3 NCT02795949 Oct 2016 → Jan 2020 bacterial infectious disease Andalusian Public Foundation for Health Research in Seville Completed Met primary
Phase 3 NCT02735707 Apr 2016 → Feb 2026 overdue pneumonia UMC Utrecht Recruiting Mixed
Phase 3 NCT02265406 Oct 2015 → Jul 2020 — Poitiers University Hospital Completed Met primary
Phase 430 trials · 2 met primary · 1 missed
Phase 4 NCT07484633 Apr 2026 → Apr 2028 expected infectious disease with sepsis Semmelweis University Not yet recruiting No outcome recorded
Phase 4 NCT06766461 Jan 2025 → Dec 2026 expected infectious disease with sepsis Erasmus Medical Center Recruiting No outcome recorded
Phase 4 NCT06423898 Oct 2024 → Jul 2027 expected infective endocarditis Andalusian Public Foundation for Health Research in Seville Recruiting No outcome recorded
Phase 4 NCT06494072 Aug 2024 → May 2028 expected — Medical College of Wisconsin Recruiting No outcome recorded
Phase 4 NCT06349122 Aug 2024 → Mar 2027 expected bacterial vaginosis Assistance Publique Hopitaux De Marseille Not yet recruiting No outcome recorded
Phase 4 NCT06396078 Jul 2024 → Dec 2026 expected preterm premature rupture of the membranes Ohio State University Recruiting No outcome recorded
Phase 4 NCT06220929 Jan → Dec 2024 infectious disease with sepsis, liver disorder Sichuan Provincial People's Hospital Unknown No outcome recorded
Phase 4 NCT05156437 Mar 2022 → Oct 2024 endocarditis West Virginia University Terminated No outcome recorded
Phase 4 NCT05079620 Nov 2021 → Apr 2024 aspiration pneumonia, aspiration pneumonitis UConn Health Terminated No outcome recorded Stop: Enrollment
Phase 4 NCT04975945 Aug → Dec 2021 — The Grant Medical College & Sir J.J. Group of Hospitals Withdrawn No outcome recorded
Phase not applicable13 trials · 1 met primary · 1 missed
— NCT07792473 Sep 2026 → Feb 2027 expected mouth mucosa disorder University of Yalova Not yet recruiting No outcome recorded
— NCT07030673 Feb 2025 → Mar 2027 expected viral infectious disease Centre Hospitalier Universitaire, Amiens Recruiting No outcome recorded
— NCT06532409 Oct 2024 → Sep 2025 overdue pneumonia RESnTEC, Institute of Research Not yet recruiting No outcome recorded
— NCT07308457 Sep 2024 → Jun 2027 expected infectious disease Pomeranian Medical University Szczecin Recruiting No outcome recorded
— NCT05750966 Jul 2023 → Apr 2026 cholangitis Academic Medical Center - University of Amsterdam Completed No outcome recorded
— NCT04839653 May 2021 → Apr 2022 acute respiratory distress syndrome, bacterial infectious disease, infectious disease with sepsis, pneumonia MEDSI Clinical Hospital 1, ICU Unknown No outcome recorded
— NCT04935515 Apr → May 2021 COVID-19 Manimarane Arjunan, MD,DM (Cardiology) Completed No outcome recorded
— NCT03518463 Jun → Jul 2017 pregnancy disorder Mbarara University of Science and Technology Completed No outcome recorded
— NCT02996656 Dec 2016 → Dec 2026 expected bacterial infectious disease University of Montreal Recruiting No outcome recorded
— NCT02334124 Jan 2015 → Jun 2017 cellulitis Murdoch Childrens Research Institute Completed Met primary
Comparator or background therapy106 trials
Phase 0 NCT06611111 Comparator Feb 2025 → Dec 2026 expected post-treatment Lyme disease syndrome State University of New York - Upstate Medical University Recruiting No outcome recorded
Phase 0 NCT05761405 Comparator Jan 2024 → Oct 2025 urinary tract infection Centre Hospitalier Universitaire Vaudois Unknown No outcome recorded
Phase 0 NCT05849090 Comparator Mar 2023 → Dec 2024 infectious disease University of Utah Completed No outcome recorded
Phase 0 NCT02099240 Comparator Mar 2014 → Nov 2018 osteomyelitis University of Louisville Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT06616168 Background Sep 2023 → Aug 2026 overdue bacterial vaginosis Danylo Halytsky Lviv National Medical University Active not recruiting No outcome recorded
Show all 106 trials opens the full record — a long page

News releases announcing trial results or a regulatory action · 2

DateIssuerRelease
2024-05-03 Basilea Pharmaceutica Results Basilea reports presentation of new data for ceftobiprole (Zevtera®) at ESCMID Global 2024 basilea.com ↗
Using the FDA-CABP-2020 primary endpoint of early clinical success at day 3 after study start, this re-analysis supported the non-inferiority of ceftobiprole to ceftriaxone ± linezolid.
2016-05-16 Theriva Biologics, Inc. Results Synthetic Biologics Announces Positive Topline Results from Second Phase 2a Clinical Trial of SYN-004 for the Prevention of C. difficile Infection and Antibiotic-Associated Diarrhea therivabio.com ↗
In addition, ceftriaxone plasma concentrations in study participants were very similar in the presence or absence of an oral PPI.

Evidence & citations 26 cited values

Every value below carries the sentence it was read from. 199 sources stand behind the page.

FieldValueCited text
Known as Ceftriaxone “Patients not already receiving a therapeutic antibiotic will be prescribed cefotaxime 1g six-hourly or ceftriaxone 1g daily, with dose adjusted as appropriate for organ...” NCT02389036 ↗
184

“Beta lactam antibiotics for non-ESBL E. coli infections include preferred ceftriaxone or alternative cephalosporins (cefepime, ceftazidime), penicillins...” NCT07318584 ↗

“Second- or third-generation cephalosporin (cefuroxime, cefotaxime, or ceftriaxone) with or without erythromycin, given parenterally; parenteral therapy should continue until...” NCT02515565 ↗

“The intravenous-group will receive Beta-lactam antimicrobials (i.e Piperacillin-Tazobactum 4.5g q 8 hourly or Ceftriaxone 1g q 12 hourly or Meropenem 1g q 8 hourly or...” NCT06847126 ↗

“empiric initiation of the enhanced spectrum antimicrobial therapy regimen (rifampin, isoniazid, linezolid, and levofloxacin) for 14 days plus standard care which includes...” NCT07332325 ↗

“The beta-lactam antibiotics with activity against gram-negative bacilli in this study included piperacillin-tazobactam, ticarcillin-clavulanate, imipenem-cilastin, meropenem,...” NCT04879030 ↗

“A combined oral care solution containing 40 mg methylprednisolone, 1000 mg ceftriaxone, and 0.84 g sodium bicarbonate will be used as a topical oral care intervention.” NCT07792473 ↗

“Ceftriaxone infusion. Ceftriaxone is a beta-lactam antibiotic that is the standard-of-care antibiotic for prophylaxis of asymptomatic bacteriuria in Switzerland.” NCT05761405 ↗

“Commonly used intravenous antibiotics (and doses) for treatment of Gram-negative bacteraemia include ceftriaxone 2 g daily or cefazolin 2 g three times daily.” NCT05199324 ↗

“Ceftriaxone (50 mg/kg once a day by intravenous/intramuscular route) AND/OR Amikacin (20 mg/kg once a day by intravenous/intramuscular route) during 3 days.” NCT05544565 ↗

“standard to double dosing of beta-lactam antibiotics (cefuroxime, ceftazidime, ceftriaxone, cefotaxime, amoxicillin, amoxicillin/clavulanic acid,” PMID 40119275 ↗ Mar 2025

Show 174 more sources

Known as Cefraden ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxon “* Ceftriaxon : 1g to 2g/day in IV, IM or SC” NCT05074147 ↗
2

NCT06090565 ↗

NCT04563325 ↗

Known as Ceftriaxona ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxone (as sodium) ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxone disodium salt ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxone disodium salt hemiheptahydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxone sodium “Anerning particle ,1 bag/time,3 times/ day, +ceftriaxone sodium,50mg/kg/time, 1 time/day, the total amount per day does not exceed 2g,for 10 days.When the condition is cured,...” NCT03675178 ↗
10

“Ceftriaxone sodium will be administered at a daily dose of 2 g (strength) when metronidazole is administered TID or at a daily dose of 4 g (strength) when metronidazole is...” NCT01473836 ↗

“Ceftriaxone sodium 2 g once daily intravenously plus metronidazole 1 g to 2 g daily given in divided doses intravenously.” NCT00195351 ↗

“Ceftriaxone sodium 2 g once daily intravenously plus metronidazole 1 g to 2 g daily given in divided doses intravenously.” NCT00230971 ↗

“Gonorrhea will be treated with a single dose of 250 mg of ceftriaxone sodium administered by intramuscular injection.” NCT00644150 ↗

“Intravenous injection of 500mg of ceftriaxone sodium (Rocephin®; Roche).” NCT03895567 ↗

“Comparator: ceftriaxone sodium /Duration of Treatment: 14 Days” NCT00451386 ↗

“Ceftriaxone sodium and Sulbactam Sodium for injection” NCT04202068 ↗

“Drug: Ceftriaxone Sodium” NCT05051163 ↗

NCT06220929 ↗

NCT05654896 ↗

Known as Ceftriaxone sodium anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxone sodium component of rocephin kit ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxone sodium hydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftriaxone sodium sesquaterhydrate ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Ceftrisol Plus “Cephalosporin- Ceftriaxone, (Ceftrisol Plus, Rocephin)” NCT05849090 ↗
Known as CRO “a single 1 g intravenous (IV) dose of ceftriaxone (CRO) plus doxycycline (DOX) versus a single 800 mg oral dose of cefixime (CFM) plus DOX for the treatment of NG-CT co-infection” PMID 35810277 ↗ Jul 2022
Known as CTRX “intravenous MNZ combined with ceftriaxone (CTRX) in Japanese subjects” PMID 25442806 ↗ Nov 2014
Known as CTX “In this pilot study, we aimed to assess the feasibility of a randomized study of whether prophylactic ceftriaxone (CTX), administered to hospitalized patients with advanced...” PMID 38180983 ↗ Jan 2024
2

“ceftriaxone (CTX): 50 mg/kg q12h (max. 4 g per day)” NCT07484633 ↗

“ceftriaxone-metronidazole (CTX/MET)” PMID 22439781 ↗ Mar 2012

Known as Megion ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as RO 13-9904 ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as RO-13-9904/001 ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Rocefin ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Known as Rocephin “The treatment involves 10 weeks of either intravenous antibiotic called ceftriaxone (also known as Rocephin) or intravenous placebo (inactive substance).” NCT00037479 ↗
6

“Here, Ceftriaxone (Rocephin®) a third generation cephalosporin will be used” NCT05398081 ↗

“a 3-week course of ceftriaxone (Rocephin) IV injection (daily dose 2g/day)” NCT05821478 ↗

“Intravenous injection of 500mg of ceftriaxone sodium (Rocephin®; Roche).” NCT03895567 ↗

“Cephalosporin- Ceftriaxone, (Ceftrisol Plus, Rocephin)” NCT05849090 ↗

“Ceftriaxone (Rocephin®)” NCT07229755 ↗

“Ceftriaxone (Rocephin®)” NCT06611111 ↗

Known as Rocephin (ceftriaxone) “Rocephin (ceftriaxone)” NCT04999592 ↗
Known as Sodium ceftriaxone, anhydrous ChEMBL registry synonym — accepted as the source's own label CHEMBL161 ↗
Action Activate “ceftriaxone increases EAAT2 activity” PMID 25297012 ↗ Oct 2014
Modality Other / unclassified “cephalosporine : ceftriaxone by intra venous route” NCT00136656 ↗