Typhoid Fever: Combined vs. Single Antibiotic Therapy

Phase 4 Unknown 120 enrolled Sheba Medical Center

RandomizedParallel-groupOpen-labelTreatment

Summary

The current study goal is to examine the effect of Cephalosporins, Azithromycin and the combination of both on typhoid fever therapy in endemic population. The investigator's hypothesize that the combination of azithromycin and ceftriaxone may prove superior to each drug, ceftriaxone or azithromycin, alone.

Timeline

Start: 2013-08
Primary completion: 2014-12
Completion: 2015-08

Publications

Zmora N, Shrestha S, Neuberger A, Paran Y, Tamrakar R, Shrestha A, Madhup SK, Bedi TRS, Koju R, Schwartz E. Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults. PLoS Negl Trop Dis. 2018 Apr 23;12(4):e0006380. doi: 10.1371/journal.pntd.0006380. eCollection 2018 Apr.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Azithromycin	Small molecule	20 mg/kg	Oral
Subject	Azithromycin	Small molecule	500 mg	Oral
Subject	Cefixime	Other / unclassified	10 mg/kg	Oral
Subject	Cefixime	Other / unclassified	400 mg	Oral
Subject	Ceftriaxone	Other / unclassified	75 mg/kg	Intravenous
Subject	Ceftriaxone	Other / unclassified	2 g	Intravenous

Typhoid Fever: Combined vs. Single Antibiotic Therapy

Summary

Timeline

Publications

Drugs

Indications