drugset / Trial / NCT04041791
A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia
Phase 3
Completed
4392 enrolled
University of Oxford
Department for International Development, United Kingdom · collabKenya Ministry of Health · collabLondon School of Hygiene and Tropical Medicine · collabMedical Research Council · collabNational Institute for Health Research, United Kingdom · collabUniversity of Nairobi · collabWellcome Trust · collab
RandomizedFactorialOpen-labelTreatment
Summary
Pneumonia is one of the top causes of death in children aged below 5. More than 10% of children with severe pneumonia die. We are not sure that the currently recommended antibiotics used in children with pneumonia are the most effective. No studies have been carried out to find out whether children with pneumonia should be given intravenous (IV) fluids or nasogastric (NG) feeds. The SEARCH trial aims to find out which antibiotics and modes of feeding are the most effective in treating children with severe pneumonia and therefore helping reduce mortality.
Timeline
- Start
- 2019-08-19
- Primary completion
- 2024-04-05
- Completion
- 2024-04-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amoxicillin | Other / unclassified | 30 mg/kg | Intravenous |
| Subject | Ampicillin | Unknown | 50 mg/kg | Intravenous |
| Subject | Benzylpenicillin | Unknown | 50000 iu/kg | Intravenous |
| Subject | Ceftriaxone | Other / unclassified | 50 mg/kg | Intravenous |
| Subject | Gentamicin | Small molecule | 7.5 mg/kg | Intravenous |