Early-onset Ventilator-associated Pneumonia in Adults: Comparison of 8 Versus 15 Days of Antibiotic Treatment
Summary
The duration of treatment of community acquired pulmonary infection varies between 5 and 14 days according to the authors (22), or even 3 days with new drugs having long half-life (2). For nosocomial pulmonary infection, treatment durations are not standardized (5). It is simply mentioned the concept of "usual" treatment of at least 15 days. However, recent studies used 10 days of treatment without significant decrease in the rate of healing compared to usual treatment. It is essential to clarify the optimal duration of antibiotic treatment. Indeed, any excessive extension of treatment may increase the occurrence of adverse effects (renal toxicities, hepatic...), and induce resistance of bacteria to antibiotics (selection pressure), colonization of the patient by Multiresistant bacteria and an increase in the cost of treatment
Timeline
- Start
- 1998-01
- Primary completion
- 2002-09
- Completion
- 2002-11
Outcome
Met primary endpoint
paper the objective of demonstrative equivalence between the 2 treatment durations was fulfilled. PMID 22952580 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amoxicillin | Other / unclassified | — | — |
| Subject | Cefotaxime | Small molecule | 1 g | — |
| Subject | Ceftriaxone | Other / unclassified | 1 g | — |
| Subject | Dibekacin | Small molecule | 5 mg/kg | — |
| Subject | Netilmicin | Small molecule | 8 mg/kg | — |
| Subject | Tobramycin | Unknown | 5 mg/kg | — |
| Subject | clavulanic acid | Small molecule | — | — |
Indications
No indication recorded.