drugset / Trial / NCT06572761
A Combination of Antibiotics to Decrease Neonatal Morbidity and Mortality for Previable Threatened Labor
Phase 3
Not yet recruiting
350 enrolled
Assistance Publique - Hôpitaux de Paris
URC-CIC Paris Descartes Necker Cochin · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to determine whether a combination of antibiotics (cephalosporin 3rd generation, clarithromycin, metronidazole) are effective to prolong pregnancies complicated with previable threatened labour with intact membranes.
Timeline
- Start
- 2026-09
- Primary completion
- 2030-05
- Completion
- 2030-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ceftriaxone | Other / unclassified | 1 g | Other |
| Subject | Clarithromycin | Small molecule | 500 mg | Oral |
| Subject | Metronidazole | Small molecule | 500 mg | Oral |
| Background | Progesterone | Other / unclassified | — | Other |