drugset / Trial / NCT05862402
Dose Optimization by Pharmacokinetic/Pharmacodynamic of Antibiotics to Improve Clinical Outcome of Carbapenem Resistant Klebsiella Pneumoniae Bloodstream Infections in Critically Ill Patients at Phramongkutklao Hospital
Phase 4
Unknown
76 enrolled
Phramongkutklao College of Medicine and Hospital
Silpakorn University · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The patients who infected with Carbapenem resistant Klebsiella pneumoniae were high mortality rate. Appropriate antibiotics therapy adjusted by Pharmacokinetic/Pharmacodynamic plays an important role in determining outcomes in Critically ill patients. Consequently, standard antibiotics dose may not be adequate to achieve pharmacokinetic/pharmacodynamic target in Critically ill patients. The purpose of this study is to compare the clinical outcomes between the critically ill patients who received antibiotics dose adjusted by pharmacokinetic/pharmacodynamic using Monte Carlo simulation and historical critically ill patients who received antibiotics from standard practice.
Timeline
- Start
- 2023-05-07
- Primary completion
- 2024-05-31
- Completion
- 2024-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amikacin | Small molecule | — | — |
| Subject | Ceftazidime-avibactam | Other / unclassified | — | — |
| Subject | Colistin | Other / unclassified | — | — |
| Subject | Gentamicin | Small molecule | — | — |
| Subject | IMIPENEM ANHYDROUS | Small molecule | — | — |
| Subject | Meropenem | Small molecule | — | — |
| Subject | Tigecycline | Small molecule | — | — |