drugset / Trial / NCT00376428
Interest of Gentamicin-induced Readthrough in Cystic Fibrosis Patients
Non-randomizedSingle-groupOpen-labelTreatment
Summary
Suppression of stop mutations in the CFTR gene with parenteral gentamicin can be predicted in vitro and is associated with clinical benefit and significant modification of the CFTR-mediated chloride transport in nasal and sweat gland epithelium.
Timeline
- Start
- 2003-01
- Primary completion
- —
- Completion
- 2005-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gentamicin | Small molecule | 10 mg/kg | Intravenous |