drugset / Trial / NCT07643974
Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD
Phase 0
Not yet recruiting
48 enrolled
Medstar Health Research Institute
United States Department of Defense · collabUniversity of Pittsburgh Medical Center · collab
RandomizedParallel-groupOpen-labelPrevention
Summary
The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex. Secondary objectives include determining whether that recolonization lasts 7, 14, or 28 days; and safety of the coupled gentamicin \& Lactobacillus instillations.
Timeline
- Start
- 2026-06
- Primary completion
- 2027-09
- Completion
- 2027-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gentamicin | Small molecule | 48 mg | Other |
| Subject | Lactobacillus rhamnosus GG | Other / unclassified | 1 unknown | Other |