Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery

NCT03081962 ↗

Phase 3 Unknown 102 enrolled Hospital General Universitario Elche

RandomizedParallel-groupTriple-blindPrevention

Summary

A prospective randomized clinical trial will be performed. Patients will be randomized in 2 groups. The experimental group will undergo the combined application of intraperitoneal irrigation with clindamycin and gentamicin solution, fascial closure with Triclosan-impregnated sutures and application of mupirocin ointment over the skin staples, in addition to the standard care measures. The control group undergo only the standard care measures. Incisional surgical-site infection will be investigated.

Timeline

Start: 2017-02-15
Primary completion: 2017-08
Completion: 2017-08

Publications

Ruiz-Tovar J, Llavero C, Morales V, Gamallo C. Effect of the application of a bundle of three measures (intraperitoneal lavage with antibiotic solution, fascial closure with Triclosan-coated sutures and Mupirocin ointment application on the skin staples) on the surgical site infection after elective laparoscopic colorectal cancer surgery. Surg Endosc. 2018 Aug;32(8):3495-3501. doi: 10.1007/s00464-018-6069-4. Epub 2018 Jan 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clindamycin	Unknown	600 mg	Other
Subject	Gentamicin	Small molecule	240 mg	Other
Subject	Mupirocin	Small molecule	—	Topical
Subject	Triclosan	Small molecule	—	—

Indications

No indication recorded.