drugset / Trial / NCT03157388
The Effect of Gut Sterilisation on Macrophage Activation in Patients With Alcoholic Hepatitis.
NaSingle-groupOpen-labelBasic science
Summary
Alcoholic hepatitis (AH) is a severe alcohol induced hepatic inflammation that leads to jaundice and liver failure. Gut derived bacterial translocation to the liver is currently thought to be one of the main inflammatory drivers of the disease. This project investigates the effects of gut sterilisation with broad spectrum antibiotics in patients with AH
Timeline
- Start
- 2017-06-01
- Primary completion
- 2018-06-01
- Completion
- 2018-12-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gentamicin | Small molecule | 40 mg | Oral |
| Subject | Meropenem | Small molecule | 500 mg | Oral |
| Subject | Vancomycin | Other / unclassified | 500 mg | Oral |